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Mutational Inactivation of Mitotic Checkpoint Genes, hsMAD2 and hBUB1, Is Rare in Sporadic Digestive Tract Cancers

Genetic instability is a key mechanism of tumorigenesis, and the instability exists at two distinct levels, the nucleotide and the chromosome levels. Disruption of the mitotic spindle checkpoint is one of the underlying mechanisms leading to aneuploidy and alterations of hsMAD2 and hBUB1, assumed to...

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Detalles Bibliográficos
Autores principales:	Imai, Yasuo, Shiratori, Yasushi, Kato, Naoya, Inoue, Tohru, Omata, Masao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 1999
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926140/ https://www.ncbi.nlm.nih.gov/pubmed/10543255 http://dx.doi.org/10.1111/j.1349-7006.1999.tb00824.x

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