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Antitumor Effects of Interleukin‐2 Gene‐modified Fibroblasts in an Orthotopic Colon Cancer Model

We transduced the interleukin‐2 (IL‐2) gene into murine fibroblasts BALBCL7 or murine colon cancer CT26 using a retroviral vector. BALBCL7 transduced with IL‐2 gene secreted 748 pg/ml of IL‐2, whereas IL‐2 gene‐modified CT26 secreted 1,167 pg/ml of IL‐2 (48 h incubation, 1×10(6)/ml). Then, we inocul...

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Detalles Bibliográficos
Autores principales:	Terasawa, Hiroshi, Tanimura, Hiroshi, Nakamori, Mikihito, Tsunoda, Takuya, Iwahashi, Makoto, Tani, Masaji, Yamaue, Hiroki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 1999
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926163/ https://www.ncbi.nlm.nih.gov/pubmed/10551331 http://dx.doi.org/10.1111/j.1349-7006.1999.tb00848.x

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