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Transduction of a Fiber‐mutant Adenovirus for the HSVtk Gene Highly Augments the Cytopathic Effect towards Gliomas

Suicide gene therapy utilizing the herpes simplex thymidine kinase (HSVtk)/ganciclovir (GCV) system has been performed to kill cancer cells. However, the low transduction efficiency of HSVtk gene into cancer cells critically limits its efficacy in cancer treatment in clinical situations. To improve...

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Detalles Bibliográficos
Autores principales:	Shinoura, Nobusada, Sakurai, Shinya, Asai, Akio, Kirino, Takaaki, Hamada, Hirofumi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2000
Materias:	Rapid Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926260/ https://www.ncbi.nlm.nih.gov/pubmed/11050474 http://dx.doi.org/10.1111/j.1349-7006.2000.tb00881.x

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