A Novel “Nihon'’Rat Model of a Mendelian Dominantly Inherited Renal Cell Carcinoma

A novel rat model of hereditary renal cell carcinoma (RC) was found in a rat colony of the Sprague‐Dawley strain in Japan, and named the “Nihon'’rat. In this strain, RCs develop from early preneoplastic lesions, which begin to appear at 4 weeks of age, forming adenomas by the age of 16 weeks. T...

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Detalles Bibliográficos
Autores principales: Okimoto, Kazuo, Kouchi, Mami, Kikawa, Emi, Toyosawa, Kaoru, Koujitani, Takatoshi, Tanaka, Kohji, Matsuoka, Nobuo, Sakurai, Junko, Hino, Okio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2000
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926279/
https://www.ncbi.nlm.nih.gov/pubmed/11092972
http://dx.doi.org/10.1111/j.1349-7006.2000.tb00890.x
Descripción
Sumario:A novel rat model of hereditary renal cell carcinoma (RC) was found in a rat colony of the Sprague‐Dawley strain in Japan, and named the “Nihon'’rat. In this strain, RCs develop from early preneoplastic lesions, which begin to appear at 4 weeks of age, forming adenomas by the age of 16 weeks. The RCs are predominantly of clear cell type. Southern blot, northern blot and SSCP analyses revealed no change in the Tsc1, Tsc2, VHL, and c‐Met genes. Thus, the Nihon rat should be a valuable experimental model for understanding renal carcinogenesis, especially clear cell type, which is common among human RCs.

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