A Novel “Nihon'’Rat Model of a Mendelian Dominantly Inherited Renal Cell Carcinoma

A novel rat model of hereditary renal cell carcinoma (RC) was found in a rat colony of the Sprague‐Dawley strain in Japan, and named the “Nihon'’rat. In this strain, RCs develop from early preneoplastic lesions, which begin to appear at 4 weeks of age, forming adenomas by the age of 16 weeks. T...

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Autores principales: Okimoto, Kazuo, Kouchi, Mami, Kikawa, Emi, Toyosawa, Kaoru, Koujitani, Takatoshi, Tanaka, Kohji, Matsuoka, Nobuo, Sakurai, Junko, Hino, Okio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2000
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926279/
https://www.ncbi.nlm.nih.gov/pubmed/11092972
http://dx.doi.org/10.1111/j.1349-7006.2000.tb00890.x
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author Okimoto, Kazuo
Kouchi, Mami
Kikawa, Emi
Toyosawa, Kaoru
Koujitani, Takatoshi
Tanaka, Kohji
Matsuoka, Nobuo
Sakurai, Junko
Hino, Okio
author_facet Okimoto, Kazuo
Kouchi, Mami
Kikawa, Emi
Toyosawa, Kaoru
Koujitani, Takatoshi
Tanaka, Kohji
Matsuoka, Nobuo
Sakurai, Junko
Hino, Okio
author_sort Okimoto, Kazuo
collection PubMed
description A novel rat model of hereditary renal cell carcinoma (RC) was found in a rat colony of the Sprague‐Dawley strain in Japan, and named the “Nihon'’rat. In this strain, RCs develop from early preneoplastic lesions, which begin to appear at 4 weeks of age, forming adenomas by the age of 16 weeks. The RCs are predominantly of clear cell type. Southern blot, northern blot and SSCP analyses revealed no change in the Tsc1, Tsc2, VHL, and c‐Met genes. Thus, the Nihon rat should be a valuable experimental model for understanding renal carcinogenesis, especially clear cell type, which is common among human RCs.
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spelling pubmed-59262792018-05-11 A Novel “Nihon'’Rat Model of a Mendelian Dominantly Inherited Renal Cell Carcinoma Okimoto, Kazuo Kouchi, Mami Kikawa, Emi Toyosawa, Kaoru Koujitani, Takatoshi Tanaka, Kohji Matsuoka, Nobuo Sakurai, Junko Hino, Okio Jpn J Cancer Res Rapid Communication A novel rat model of hereditary renal cell carcinoma (RC) was found in a rat colony of the Sprague‐Dawley strain in Japan, and named the “Nihon'’rat. In this strain, RCs develop from early preneoplastic lesions, which begin to appear at 4 weeks of age, forming adenomas by the age of 16 weeks. The RCs are predominantly of clear cell type. Southern blot, northern blot and SSCP analyses revealed no change in the Tsc1, Tsc2, VHL, and c‐Met genes. Thus, the Nihon rat should be a valuable experimental model for understanding renal carcinogenesis, especially clear cell type, which is common among human RCs. Blackwell Publishing Ltd 2000-11 /pmc/articles/PMC5926279/ /pubmed/11092972 http://dx.doi.org/10.1111/j.1349-7006.2000.tb00890.x Text en
spellingShingle Rapid Communication
Okimoto, Kazuo
Kouchi, Mami
Kikawa, Emi
Toyosawa, Kaoru
Koujitani, Takatoshi
Tanaka, Kohji
Matsuoka, Nobuo
Sakurai, Junko
Hino, Okio
A Novel “Nihon'’Rat Model of a Mendelian Dominantly Inherited Renal Cell Carcinoma
title A Novel “Nihon'’Rat Model of a Mendelian Dominantly Inherited Renal Cell Carcinoma
title_full A Novel “Nihon'’Rat Model of a Mendelian Dominantly Inherited Renal Cell Carcinoma
title_fullStr A Novel “Nihon'’Rat Model of a Mendelian Dominantly Inherited Renal Cell Carcinoma
title_full_unstemmed A Novel “Nihon'’Rat Model of a Mendelian Dominantly Inherited Renal Cell Carcinoma
title_short A Novel “Nihon'’Rat Model of a Mendelian Dominantly Inherited Renal Cell Carcinoma
title_sort novel “nihon'’rat model of a mendelian dominantly inherited renal cell carcinoma
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926279/
https://www.ncbi.nlm.nih.gov/pubmed/11092972
http://dx.doi.org/10.1111/j.1349-7006.2000.tb00890.x
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