An Experimental Model of Tumor Dormancy Therapy for Advanced Head and Neck Carcinoma

An experimental model of tumor dormancy therapy for advanced head and neck carcinoma was developed. After transplantation of KB cells into nude mice, the mice were given tiracoxib, a selective cyclooxygenase (COX)‐2 inhibitor, probucol, an antioxidant, and S‐1, an oral pro‐drug of 5‐fluorouracil (5‐...

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Autores principales: Nishimura, Goshi, Yanoma, Shunsuke, Satake, Kenichi, Ikeda, Yoichi, Taguchi, Takahide, Nakamura, Yoshiyasu, Hirose, Fumikazu, Tsukuda, Mamoru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2000
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926286/
https://www.ncbi.nlm.nih.gov/pubmed/11092987
http://dx.doi.org/10.1111/j.1349-7006.2000.tb00905.x
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author Nishimura, Goshi
Yanoma, Shunsuke
Satake, Kenichi
Ikeda, Yoichi
Taguchi, Takahide
Nakamura, Yoshiyasu
Hirose, Fumikazu
Tsukuda, Mamoru
author_facet Nishimura, Goshi
Yanoma, Shunsuke
Satake, Kenichi
Ikeda, Yoichi
Taguchi, Takahide
Nakamura, Yoshiyasu
Hirose, Fumikazu
Tsukuda, Mamoru
author_sort Nishimura, Goshi
collection PubMed
description An experimental model of tumor dormancy therapy for advanced head and neck carcinoma was developed. After transplantation of KB cells into nude mice, the mice were given tiracoxib, a selective cyclooxygenase (COX)‐2 inhibitor, probucol, an antioxidant, and S‐1, an oral pro‐drug of 5‐fluorouracil (5‐FU), or combinations of two of them. The combined administration of tiracoxib with probucol significantly inhibited the tumor growth. The angiogenesis in this group was markedly reduced. Tiracoxib and probucol did not affect the intratumoral concentration of 5‐FU when coadministered with S‐1. The combined use of tiracoxib and probucol is thus a candidate for use in maintenance therapy after the primary therapy for patients with advanced head and neck carcinoma.
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spelling pubmed-59262862018-05-11 An Experimental Model of Tumor Dormancy Therapy for Advanced Head and Neck Carcinoma Nishimura, Goshi Yanoma, Shunsuke Satake, Kenichi Ikeda, Yoichi Taguchi, Takahide Nakamura, Yoshiyasu Hirose, Fumikazu Tsukuda, Mamoru Jpn J Cancer Res Rapid Communication An experimental model of tumor dormancy therapy for advanced head and neck carcinoma was developed. After transplantation of KB cells into nude mice, the mice were given tiracoxib, a selective cyclooxygenase (COX)‐2 inhibitor, probucol, an antioxidant, and S‐1, an oral pro‐drug of 5‐fluorouracil (5‐FU), or combinations of two of them. The combined administration of tiracoxib with probucol significantly inhibited the tumor growth. The angiogenesis in this group was markedly reduced. Tiracoxib and probucol did not affect the intratumoral concentration of 5‐FU when coadministered with S‐1. The combined use of tiracoxib and probucol is thus a candidate for use in maintenance therapy after the primary therapy for patients with advanced head and neck carcinoma. Blackwell Publishing Ltd 2000-11 /pmc/articles/PMC5926286/ /pubmed/11092987 http://dx.doi.org/10.1111/j.1349-7006.2000.tb00905.x Text en
spellingShingle Rapid Communication
Nishimura, Goshi
Yanoma, Shunsuke
Satake, Kenichi
Ikeda, Yoichi
Taguchi, Takahide
Nakamura, Yoshiyasu
Hirose, Fumikazu
Tsukuda, Mamoru
An Experimental Model of Tumor Dormancy Therapy for Advanced Head and Neck Carcinoma
title An Experimental Model of Tumor Dormancy Therapy for Advanced Head and Neck Carcinoma
title_full An Experimental Model of Tumor Dormancy Therapy for Advanced Head and Neck Carcinoma
title_fullStr An Experimental Model of Tumor Dormancy Therapy for Advanced Head and Neck Carcinoma
title_full_unstemmed An Experimental Model of Tumor Dormancy Therapy for Advanced Head and Neck Carcinoma
title_short An Experimental Model of Tumor Dormancy Therapy for Advanced Head and Neck Carcinoma
title_sort experimental model of tumor dormancy therapy for advanced head and neck carcinoma
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926286/
https://www.ncbi.nlm.nih.gov/pubmed/11092987
http://dx.doi.org/10.1111/j.1349-7006.2000.tb00905.x
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