UCN‐01 (7‐Hydroxystaurosporine) Enhances 5‐Fluorouracil Cytotoxicity through Down‐regulation of Thymidylate Synthetase Messenger RNA

UCN‐01 (7‐hydroxystaurosporine) is a newly developed cell cycle inhibitor known to have several modes of action, including inhibition of cyclin‐dependent kinase, induction of p21 and suppression of pRb phosphorylation. In order to test a combination therapy of UCN‐01 and 5‐fluorouracil (5‐FU), growt...

Descripción completa

Detalles Bibliográficos
Autores principales: Abe, Sadanori, Kubota, Tetsuro, Otani, Yoshihide, Furukawa, Toshiharu, Watanabe, Masahiko, Kumai, Koichiro, Kitajima, Masaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2000
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926291/
https://www.ncbi.nlm.nih.gov/pubmed/11092986
http://dx.doi.org/10.1111/j.1349-7006.2000.tb00904.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926291/
https://www.ncbi.nlm.nih.gov/pubmed/11092986
http://dx.doi.org/10.1111/j.1349-7006.2000.tb00904.x

Ejemplares similares