Sonodynamically Induced Antitumor Effect of 4‐Formyloximethylidene‐3‐Hydroxy‐2‐vinyl‐deuterio‐porphynyl(IX)‐6,7‐diaspartic Acid (ATX‐S10)

The sonodynamically induced antitumor effect of 4‐formyloximethylidene‐3‐hydroxy‐2‐vinyl‐deuterio‐porphynyl(IX)‐6,7‐diaspartic acid (ATX‐S10) was investigated. Both in vitro and in vivo antitumor effects were tested in combination with ultrasound at 2 MHz. The rate of ultrasonically induced damage t...

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Detalles Bibliográficos
Autores principales: Yumita, Nagahiko, Nishigaki, Ryuichiro, Sakata, Isao, Nakajima, Susumu, Umemura, Shin‐ichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2000
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926330/
https://www.ncbi.nlm.nih.gov/pubmed/10761714
http://dx.doi.org/10.1111/j.1349-7006.2000.tb00939.x
Descripción
Sumario:The sonodynamically induced antitumor effect of 4‐formyloximethylidene‐3‐hydroxy‐2‐vinyl‐deuterio‐porphynyl(IX)‐6,7‐diaspartic acid (ATX‐S10) was investigated. Both in vitro and in vivo antitumor effects were tested in combination with ultrasound at 2 MHz. The rate of ultrasonically induced damage to isolated sarcoma 180 cells in air‐saturated suspension was enhanced two‐fold with 80 μM ATX‐S10. This enhancement was significantly inhibited by histidine, which may suggest that it was mediated by ultrasonically induced oxidation. The coadministraion of 25 mg/kg ATX‐S10 followed by ultrasonic exposure at 2 MHz stopped the growth of implanted colon 26 tumors at an intensity at which ultrasound alone showed only a slight antitumor effect.

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