Sonodynamically Induced Antitumor Effect of 4‐Formyloximethylidene‐3‐Hydroxy‐2‐vinyl‐deuterio‐porphynyl(IX)‐6,7‐diaspartic Acid (ATX‐S10)

The sonodynamically induced antitumor effect of 4‐formyloximethylidene‐3‐hydroxy‐2‐vinyl‐deuterio‐porphynyl(IX)‐6,7‐diaspartic acid (ATX‐S10) was investigated. Both in vitro and in vivo antitumor effects were tested in combination with ultrasound at 2 MHz. The rate of ultrasonically induced damage t...

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Autores principales: Yumita, Nagahiko, Nishigaki, Ryuichiro, Sakata, Isao, Nakajima, Susumu, Umemura, Shin‐ichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2000
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926330/
https://www.ncbi.nlm.nih.gov/pubmed/10761714
http://dx.doi.org/10.1111/j.1349-7006.2000.tb00939.x
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author Yumita, Nagahiko
Nishigaki, Ryuichiro
Sakata, Isao
Nakajima, Susumu
Umemura, Shin‐ichiro
author_facet Yumita, Nagahiko
Nishigaki, Ryuichiro
Sakata, Isao
Nakajima, Susumu
Umemura, Shin‐ichiro
author_sort Yumita, Nagahiko
collection PubMed
description The sonodynamically induced antitumor effect of 4‐formyloximethylidene‐3‐hydroxy‐2‐vinyl‐deuterio‐porphynyl(IX)‐6,7‐diaspartic acid (ATX‐S10) was investigated. Both in vitro and in vivo antitumor effects were tested in combination with ultrasound at 2 MHz. The rate of ultrasonically induced damage to isolated sarcoma 180 cells in air‐saturated suspension was enhanced two‐fold with 80 μM ATX‐S10. This enhancement was significantly inhibited by histidine, which may suggest that it was mediated by ultrasonically induced oxidation. The coadministraion of 25 mg/kg ATX‐S10 followed by ultrasonic exposure at 2 MHz stopped the growth of implanted colon 26 tumors at an intensity at which ultrasound alone showed only a slight antitumor effect.
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spelling pubmed-59263302018-05-11 Sonodynamically Induced Antitumor Effect of 4‐Formyloximethylidene‐3‐Hydroxy‐2‐vinyl‐deuterio‐porphynyl(IX)‐6,7‐diaspartic Acid (ATX‐S10) Yumita, Nagahiko Nishigaki, Ryuichiro Sakata, Isao Nakajima, Susumu Umemura, Shin‐ichiro Jpn J Cancer Res Article The sonodynamically induced antitumor effect of 4‐formyloximethylidene‐3‐hydroxy‐2‐vinyl‐deuterio‐porphynyl(IX)‐6,7‐diaspartic acid (ATX‐S10) was investigated. Both in vitro and in vivo antitumor effects were tested in combination with ultrasound at 2 MHz. The rate of ultrasonically induced damage to isolated sarcoma 180 cells in air‐saturated suspension was enhanced two‐fold with 80 μM ATX‐S10. This enhancement was significantly inhibited by histidine, which may suggest that it was mediated by ultrasonically induced oxidation. The coadministraion of 25 mg/kg ATX‐S10 followed by ultrasonic exposure at 2 MHz stopped the growth of implanted colon 26 tumors at an intensity at which ultrasound alone showed only a slight antitumor effect. Blackwell Publishing Ltd 2000-02 /pmc/articles/PMC5926330/ /pubmed/10761714 http://dx.doi.org/10.1111/j.1349-7006.2000.tb00939.x Text en
spellingShingle Article
Yumita, Nagahiko
Nishigaki, Ryuichiro
Sakata, Isao
Nakajima, Susumu
Umemura, Shin‐ichiro
Sonodynamically Induced Antitumor Effect of 4‐Formyloximethylidene‐3‐Hydroxy‐2‐vinyl‐deuterio‐porphynyl(IX)‐6,7‐diaspartic Acid (ATX‐S10)
title Sonodynamically Induced Antitumor Effect of 4‐Formyloximethylidene‐3‐Hydroxy‐2‐vinyl‐deuterio‐porphynyl(IX)‐6,7‐diaspartic Acid (ATX‐S10)
title_full Sonodynamically Induced Antitumor Effect of 4‐Formyloximethylidene‐3‐Hydroxy‐2‐vinyl‐deuterio‐porphynyl(IX)‐6,7‐diaspartic Acid (ATX‐S10)
title_fullStr Sonodynamically Induced Antitumor Effect of 4‐Formyloximethylidene‐3‐Hydroxy‐2‐vinyl‐deuterio‐porphynyl(IX)‐6,7‐diaspartic Acid (ATX‐S10)
title_full_unstemmed Sonodynamically Induced Antitumor Effect of 4‐Formyloximethylidene‐3‐Hydroxy‐2‐vinyl‐deuterio‐porphynyl(IX)‐6,7‐diaspartic Acid (ATX‐S10)
title_short Sonodynamically Induced Antitumor Effect of 4‐Formyloximethylidene‐3‐Hydroxy‐2‐vinyl‐deuterio‐porphynyl(IX)‐6,7‐diaspartic Acid (ATX‐S10)
title_sort sonodynamically induced antitumor effect of 4‐formyloximethylidene‐3‐hydroxy‐2‐vinyl‐deuterio‐porphynyl(ix)‐6,7‐diaspartic acid (atx‐s10)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926330/
https://www.ncbi.nlm.nih.gov/pubmed/10761714
http://dx.doi.org/10.1111/j.1349-7006.2000.tb00939.x
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