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Inhibitory Effects of 1′‐Acetoxychavicol Acetate on N‐Nitrosobis(2‐oxopropyl)‐amine‐induced Initiation of Cholangiocarcinogenesis in Syrian Hamsters

The influence of 1′‐acetoxychavicol acetate (ACA) during the initiation stage was investigated in the N‐nitrosobis(2‐oxopropyl)amine (BOP)‐initiated hamster tumorigenesis model. Ninety male 5‐week‐old hamsters were divided into three groups, each consisting of 30 animals, and s.c. injected with 20 m...

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Autores principales: Miyauchi, Makoto, Nishikawa, Akiyoshi, Furukawa, Fumio, Nakamura, Hideaki, Son, Hwa‐ Young, Murakami, Akira, Koshimizu, Koichi, Ohigashi, Hajime, Hirose, Masao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2000
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926388/
https://www.ncbi.nlm.nih.gov/pubmed/10835491
http://dx.doi.org/10.1111/j.1349-7006.2000.tb00970.x
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author Miyauchi, Makoto
Nishikawa, Akiyoshi
Furukawa, Fumio
Nakamura, Hideaki
Son, Hwa‐ Young
Murakami, Akira
Koshimizu, Koichi
Ohigashi, Hajime
Hirose, Masao
author_facet Miyauchi, Makoto
Nishikawa, Akiyoshi
Furukawa, Fumio
Nakamura, Hideaki
Son, Hwa‐ Young
Murakami, Akira
Koshimizu, Koichi
Ohigashi, Hajime
Hirose, Masao
author_sort Miyauchi, Makoto
collection PubMed
description The influence of 1′‐acetoxychavicol acetate (ACA) during the initiation stage was investigated in the N‐nitrosobis(2‐oxopropyl)amine (BOP)‐initiated hamster tumorigenesis model. Ninety male 5‐week‐old hamsters were divided into three groups, each consisting of 30 animals, and s.c. injected with 20 mg/kg of BOP twice with a one‐week interval. Groups 1 through 3 were fed diet supplemented with ACA at concentrations of 500, 100 and 0 ppm, respectively, for 3 weeks starting one week before the first carcinogen application. At the termination of experimental week 54, the total incidence and multiplicity of cholangiocellular adenomas and carcinomas in group 1 (17.9% and 0.3±0.9) were significantly (P< 0.05 and P< 0.01) decreased as compared to the group 3 values (50.0% and 0.7±0.8). The ACA treatments also showed a tendency to reduce the development of preneoplastic lesions in the pancreas, a main target organ of BOP, although this was not statistically significant. Our results thus indicate that ACA exerts an inhibitory effect on BOP‐induced cholangiocarcinogenesis in hamsters. Taken together with previous findings of inhibited colon, oral and skin carcinogenesis in rats and mice, they suggest that ACA is a candidate chemopreventive agent with a wide spectrum of activity.
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spelling pubmed-59263882018-05-11 Inhibitory Effects of 1′‐Acetoxychavicol Acetate on N‐Nitrosobis(2‐oxopropyl)‐amine‐induced Initiation of Cholangiocarcinogenesis in Syrian Hamsters Miyauchi, Makoto Nishikawa, Akiyoshi Furukawa, Fumio Nakamura, Hideaki Son, Hwa‐ Young Murakami, Akira Koshimizu, Koichi Ohigashi, Hajime Hirose, Masao Jpn J Cancer Res Article The influence of 1′‐acetoxychavicol acetate (ACA) during the initiation stage was investigated in the N‐nitrosobis(2‐oxopropyl)amine (BOP)‐initiated hamster tumorigenesis model. Ninety male 5‐week‐old hamsters were divided into three groups, each consisting of 30 animals, and s.c. injected with 20 mg/kg of BOP twice with a one‐week interval. Groups 1 through 3 were fed diet supplemented with ACA at concentrations of 500, 100 and 0 ppm, respectively, for 3 weeks starting one week before the first carcinogen application. At the termination of experimental week 54, the total incidence and multiplicity of cholangiocellular adenomas and carcinomas in group 1 (17.9% and 0.3±0.9) were significantly (P< 0.05 and P< 0.01) decreased as compared to the group 3 values (50.0% and 0.7±0.8). The ACA treatments also showed a tendency to reduce the development of preneoplastic lesions in the pancreas, a main target organ of BOP, although this was not statistically significant. Our results thus indicate that ACA exerts an inhibitory effect on BOP‐induced cholangiocarcinogenesis in hamsters. Taken together with previous findings of inhibited colon, oral and skin carcinogenesis in rats and mice, they suggest that ACA is a candidate chemopreventive agent with a wide spectrum of activity. Blackwell Publishing Ltd 2000-05 /pmc/articles/PMC5926388/ /pubmed/10835491 http://dx.doi.org/10.1111/j.1349-7006.2000.tb00970.x Text en
spellingShingle Article
Miyauchi, Makoto
Nishikawa, Akiyoshi
Furukawa, Fumio
Nakamura, Hideaki
Son, Hwa‐ Young
Murakami, Akira
Koshimizu, Koichi
Ohigashi, Hajime
Hirose, Masao
Inhibitory Effects of 1′‐Acetoxychavicol Acetate on N‐Nitrosobis(2‐oxopropyl)‐amine‐induced Initiation of Cholangiocarcinogenesis in Syrian Hamsters
title Inhibitory Effects of 1′‐Acetoxychavicol Acetate on N‐Nitrosobis(2‐oxopropyl)‐amine‐induced Initiation of Cholangiocarcinogenesis in Syrian Hamsters
title_full Inhibitory Effects of 1′‐Acetoxychavicol Acetate on N‐Nitrosobis(2‐oxopropyl)‐amine‐induced Initiation of Cholangiocarcinogenesis in Syrian Hamsters
title_fullStr Inhibitory Effects of 1′‐Acetoxychavicol Acetate on N‐Nitrosobis(2‐oxopropyl)‐amine‐induced Initiation of Cholangiocarcinogenesis in Syrian Hamsters
title_full_unstemmed Inhibitory Effects of 1′‐Acetoxychavicol Acetate on N‐Nitrosobis(2‐oxopropyl)‐amine‐induced Initiation of Cholangiocarcinogenesis in Syrian Hamsters
title_short Inhibitory Effects of 1′‐Acetoxychavicol Acetate on N‐Nitrosobis(2‐oxopropyl)‐amine‐induced Initiation of Cholangiocarcinogenesis in Syrian Hamsters
title_sort inhibitory effects of 1′‐acetoxychavicol acetate on n‐nitrosobis(2‐oxopropyl)‐amine‐induced initiation of cholangiocarcinogenesis in syrian hamsters
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926388/
https://www.ncbi.nlm.nih.gov/pubmed/10835491
http://dx.doi.org/10.1111/j.1349-7006.2000.tb00970.x
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