Cargando…
Inhibitory Effects of 1′‐Acetoxychavicol Acetate on N‐Nitrosobis(2‐oxopropyl)‐amine‐induced Initiation of Cholangiocarcinogenesis in Syrian Hamsters
The influence of 1′‐acetoxychavicol acetate (ACA) during the initiation stage was investigated in the N‐nitrosobis(2‐oxopropyl)amine (BOP)‐initiated hamster tumorigenesis model. Ninety male 5‐week‐old hamsters were divided into three groups, each consisting of 30 animals, and s.c. injected with 20 m...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2000
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926388/ https://www.ncbi.nlm.nih.gov/pubmed/10835491 http://dx.doi.org/10.1111/j.1349-7006.2000.tb00970.x |
_version_ | 1783318895145254912 |
---|---|
author | Miyauchi, Makoto Nishikawa, Akiyoshi Furukawa, Fumio Nakamura, Hideaki Son, Hwa‐ Young Murakami, Akira Koshimizu, Koichi Ohigashi, Hajime Hirose, Masao |
author_facet | Miyauchi, Makoto Nishikawa, Akiyoshi Furukawa, Fumio Nakamura, Hideaki Son, Hwa‐ Young Murakami, Akira Koshimizu, Koichi Ohigashi, Hajime Hirose, Masao |
author_sort | Miyauchi, Makoto |
collection | PubMed |
description | The influence of 1′‐acetoxychavicol acetate (ACA) during the initiation stage was investigated in the N‐nitrosobis(2‐oxopropyl)amine (BOP)‐initiated hamster tumorigenesis model. Ninety male 5‐week‐old hamsters were divided into three groups, each consisting of 30 animals, and s.c. injected with 20 mg/kg of BOP twice with a one‐week interval. Groups 1 through 3 were fed diet supplemented with ACA at concentrations of 500, 100 and 0 ppm, respectively, for 3 weeks starting one week before the first carcinogen application. At the termination of experimental week 54, the total incidence and multiplicity of cholangiocellular adenomas and carcinomas in group 1 (17.9% and 0.3±0.9) were significantly (P< 0.05 and P< 0.01) decreased as compared to the group 3 values (50.0% and 0.7±0.8). The ACA treatments also showed a tendency to reduce the development of preneoplastic lesions in the pancreas, a main target organ of BOP, although this was not statistically significant. Our results thus indicate that ACA exerts an inhibitory effect on BOP‐induced cholangiocarcinogenesis in hamsters. Taken together with previous findings of inhibited colon, oral and skin carcinogenesis in rats and mice, they suggest that ACA is a candidate chemopreventive agent with a wide spectrum of activity. |
format | Online Article Text |
id | pubmed-5926388 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2000 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-59263882018-05-11 Inhibitory Effects of 1′‐Acetoxychavicol Acetate on N‐Nitrosobis(2‐oxopropyl)‐amine‐induced Initiation of Cholangiocarcinogenesis in Syrian Hamsters Miyauchi, Makoto Nishikawa, Akiyoshi Furukawa, Fumio Nakamura, Hideaki Son, Hwa‐ Young Murakami, Akira Koshimizu, Koichi Ohigashi, Hajime Hirose, Masao Jpn J Cancer Res Article The influence of 1′‐acetoxychavicol acetate (ACA) during the initiation stage was investigated in the N‐nitrosobis(2‐oxopropyl)amine (BOP)‐initiated hamster tumorigenesis model. Ninety male 5‐week‐old hamsters were divided into three groups, each consisting of 30 animals, and s.c. injected with 20 mg/kg of BOP twice with a one‐week interval. Groups 1 through 3 were fed diet supplemented with ACA at concentrations of 500, 100 and 0 ppm, respectively, for 3 weeks starting one week before the first carcinogen application. At the termination of experimental week 54, the total incidence and multiplicity of cholangiocellular adenomas and carcinomas in group 1 (17.9% and 0.3±0.9) were significantly (P< 0.05 and P< 0.01) decreased as compared to the group 3 values (50.0% and 0.7±0.8). The ACA treatments also showed a tendency to reduce the development of preneoplastic lesions in the pancreas, a main target organ of BOP, although this was not statistically significant. Our results thus indicate that ACA exerts an inhibitory effect on BOP‐induced cholangiocarcinogenesis in hamsters. Taken together with previous findings of inhibited colon, oral and skin carcinogenesis in rats and mice, they suggest that ACA is a candidate chemopreventive agent with a wide spectrum of activity. Blackwell Publishing Ltd 2000-05 /pmc/articles/PMC5926388/ /pubmed/10835491 http://dx.doi.org/10.1111/j.1349-7006.2000.tb00970.x Text en |
spellingShingle | Article Miyauchi, Makoto Nishikawa, Akiyoshi Furukawa, Fumio Nakamura, Hideaki Son, Hwa‐ Young Murakami, Akira Koshimizu, Koichi Ohigashi, Hajime Hirose, Masao Inhibitory Effects of 1′‐Acetoxychavicol Acetate on N‐Nitrosobis(2‐oxopropyl)‐amine‐induced Initiation of Cholangiocarcinogenesis in Syrian Hamsters |
title | Inhibitory Effects of 1′‐Acetoxychavicol Acetate on N‐Nitrosobis(2‐oxopropyl)‐amine‐induced Initiation of Cholangiocarcinogenesis in Syrian Hamsters |
title_full | Inhibitory Effects of 1′‐Acetoxychavicol Acetate on N‐Nitrosobis(2‐oxopropyl)‐amine‐induced Initiation of Cholangiocarcinogenesis in Syrian Hamsters |
title_fullStr | Inhibitory Effects of 1′‐Acetoxychavicol Acetate on N‐Nitrosobis(2‐oxopropyl)‐amine‐induced Initiation of Cholangiocarcinogenesis in Syrian Hamsters |
title_full_unstemmed | Inhibitory Effects of 1′‐Acetoxychavicol Acetate on N‐Nitrosobis(2‐oxopropyl)‐amine‐induced Initiation of Cholangiocarcinogenesis in Syrian Hamsters |
title_short | Inhibitory Effects of 1′‐Acetoxychavicol Acetate on N‐Nitrosobis(2‐oxopropyl)‐amine‐induced Initiation of Cholangiocarcinogenesis in Syrian Hamsters |
title_sort | inhibitory effects of 1′‐acetoxychavicol acetate on n‐nitrosobis(2‐oxopropyl)‐amine‐induced initiation of cholangiocarcinogenesis in syrian hamsters |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926388/ https://www.ncbi.nlm.nih.gov/pubmed/10835491 http://dx.doi.org/10.1111/j.1349-7006.2000.tb00970.x |
work_keys_str_mv | AT miyauchimakoto inhibitoryeffectsof1acetoxychavicolacetateonnnitrosobis2oxopropylamineinducedinitiationofcholangiocarcinogenesisinsyrianhamsters AT nishikawaakiyoshi inhibitoryeffectsof1acetoxychavicolacetateonnnitrosobis2oxopropylamineinducedinitiationofcholangiocarcinogenesisinsyrianhamsters AT furukawafumio inhibitoryeffectsof1acetoxychavicolacetateonnnitrosobis2oxopropylamineinducedinitiationofcholangiocarcinogenesisinsyrianhamsters AT nakamurahideaki inhibitoryeffectsof1acetoxychavicolacetateonnnitrosobis2oxopropylamineinducedinitiationofcholangiocarcinogenesisinsyrianhamsters AT sonhwayoung inhibitoryeffectsof1acetoxychavicolacetateonnnitrosobis2oxopropylamineinducedinitiationofcholangiocarcinogenesisinsyrianhamsters AT murakamiakira inhibitoryeffectsof1acetoxychavicolacetateonnnitrosobis2oxopropylamineinducedinitiationofcholangiocarcinogenesisinsyrianhamsters AT koshimizukoichi inhibitoryeffectsof1acetoxychavicolacetateonnnitrosobis2oxopropylamineinducedinitiationofcholangiocarcinogenesisinsyrianhamsters AT ohigashihajime inhibitoryeffectsof1acetoxychavicolacetateonnnitrosobis2oxopropylamineinducedinitiationofcholangiocarcinogenesisinsyrianhamsters AT hirosemasao inhibitoryeffectsof1acetoxychavicolacetateonnnitrosobis2oxopropylamineinducedinitiationofcholangiocarcinogenesisinsyrianhamsters |