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Spicamycin and KRN5500 Induce Apoptosis in Myeloid and Lymphoid Cell Lines with Down‐regulation of Bcl‐2 Expression and Modulation of Promyelocytic Leukemia Protein

Spicamycin is a potent inducer of differentiation of human myeloid leukemia cells (HL‐60) and murine myeloid leukemia cells (M1). One of the spicamycin derivatives, KRN5500, shows a broad spectrum of antitumor activity against human tumor xenografts in nude mice. In this study, we first investigated...

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Detalles Bibliográficos
Autores principales:	Zhang, Wen Jie, Ohnishi, Kazunori, Yoshida, Hitoshi, Pan, Ling, Maksumova, Lola, Muratkhodjaev, Farkhad, Luo, Jian Min, Shigeno, Kazuyuki, Fujisawa, Shinya, Naito, Kensuke, Nakamura, Satoki, Shinjo, Kaori, Takeshita, Akihiro, Ohno, Ryuzo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2000
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926402/ https://www.ncbi.nlm.nih.gov/pubmed/10874212 http://dx.doi.org/10.1111/j.1349-7006.2000.tb00988.x

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