Mouse Strain Susceptibility to Diethylnitrosamine Induced Hepatocarcinogenesis Is Cell Autonomous Whereas Sex‐susceptibility Is Due to the Micro‐environment: Analysis with C3H ↔ BALB/c Sexually Chimeric Mice

In man, liver cancer is on the increase, especially in males. Sex differences also exist in rodent models. To elucidate the mechanisms, chimeric mice were produced by amalgamation of early embryos from high and low hepatocarcinogen‐susceptible strains, C3H and BALB/c. Tumor formation was initiated w...

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Detalles Bibliográficos
Autores principales: Tsukamoto, Tetsuya, Inada, Ken‐ichi, Fukami, Hiroko, Yamamoto, Masami, Tanaka, Harunari, Kusakabe, Moriaki, Bishop, Colin E., Tatematsu, Masae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2000
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926415/
https://www.ncbi.nlm.nih.gov/pubmed/10920272
http://dx.doi.org/10.1111/j.1349-7006.2000.tb00997.x

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