Cargando…

Co‐expression of Thymidine Phosphorylase and Heme Oxygenase‐1 in Macrophages in Human Malignant Vertical Growth Melanomas

Expression of thymidine phosphorylase (TP) is often associated with tumor angiogenesis and/or prognosis in patients. Further, infiltration of macrophages is closely correlated with the depth of tumor and angiogenesis in melanomas. In this study, we examined the expression of TP and an activated macr...

Descripción completa

Detalles Bibliográficos
Autores principales: Torisu‐Itakura, Hitoe, Furue, Masutaka, Kuwano, Michihiko, Ono, Mayumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2000
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926440/
https://www.ncbi.nlm.nih.gov/pubmed/11011118
http://dx.doi.org/10.1111/j.1349-7006.2000.tb01033.x
_version_ 1783318906809614336
author Torisu‐Itakura, Hitoe
Furue, Masutaka
Kuwano, Michihiko
Ono, Mayumi
author_facet Torisu‐Itakura, Hitoe
Furue, Masutaka
Kuwano, Michihiko
Ono, Mayumi
author_sort Torisu‐Itakura, Hitoe
collection PubMed
description Expression of thymidine phosphorylase (TP) is often associated with tumor angiogenesis and/or prognosis in patients. Further, infiltration of macrophages is closely correlated with the depth of tumor and angiogenesis in melanomas. In this study, we examined the expression of TP and an activated macrophage‐specific enzyme, heme oxygenase‐1 (HO‐1), involved in malignancy in 22 cases with melanomas. TP was strongly expressed not only in CD68‐positive macrophages in and around tumors, but also in S100 protein‐positive melanoma cells, fibroblasts and keratinocytes. By contrast, HO‐1 was specifically expressed in macrophages, but only slightly in melanoma cells and other cell types in the stroma of melanomas. We thus observed apparent co‐expression of TP and HO‐1 in macrophages infiltrating in the late stage of malignant melanomas. There appeared increasing numbers of TP‐positive cells in Clark level IV and V melanoma compared with Clark level I (in situ) melanoma, and there was also a close correlation between numbers of TP‐positive cells and HO‐1‐positive cells. Both TP‐ and HO‐1‐positive macrophages could be observed in the stroma in and around tumors in vertical growth melanomas.
format Online
Article
Text
id pubmed-5926440
institution National Center for Biotechnology Information
language English
publishDate 2000
publisher Blackwell Publishing Ltd
record_format MEDLINE/PubMed
spelling pubmed-59264402018-05-11 Co‐expression of Thymidine Phosphorylase and Heme Oxygenase‐1 in Macrophages in Human Malignant Vertical Growth Melanomas Torisu‐Itakura, Hitoe Furue, Masutaka Kuwano, Michihiko Ono, Mayumi Jpn J Cancer Res Article Expression of thymidine phosphorylase (TP) is often associated with tumor angiogenesis and/or prognosis in patients. Further, infiltration of macrophages is closely correlated with the depth of tumor and angiogenesis in melanomas. In this study, we examined the expression of TP and an activated macrophage‐specific enzyme, heme oxygenase‐1 (HO‐1), involved in malignancy in 22 cases with melanomas. TP was strongly expressed not only in CD68‐positive macrophages in and around tumors, but also in S100 protein‐positive melanoma cells, fibroblasts and keratinocytes. By contrast, HO‐1 was specifically expressed in macrophages, but only slightly in melanoma cells and other cell types in the stroma of melanomas. We thus observed apparent co‐expression of TP and HO‐1 in macrophages infiltrating in the late stage of malignant melanomas. There appeared increasing numbers of TP‐positive cells in Clark level IV and V melanoma compared with Clark level I (in situ) melanoma, and there was also a close correlation between numbers of TP‐positive cells and HO‐1‐positive cells. Both TP‐ and HO‐1‐positive macrophages could be observed in the stroma in and around tumors in vertical growth melanomas. Blackwell Publishing Ltd 2000-09 /pmc/articles/PMC5926440/ /pubmed/11011118 http://dx.doi.org/10.1111/j.1349-7006.2000.tb01033.x Text en
spellingShingle Article
Torisu‐Itakura, Hitoe
Furue, Masutaka
Kuwano, Michihiko
Ono, Mayumi
Co‐expression of Thymidine Phosphorylase and Heme Oxygenase‐1 in Macrophages in Human Malignant Vertical Growth Melanomas
title Co‐expression of Thymidine Phosphorylase and Heme Oxygenase‐1 in Macrophages in Human Malignant Vertical Growth Melanomas
title_full Co‐expression of Thymidine Phosphorylase and Heme Oxygenase‐1 in Macrophages in Human Malignant Vertical Growth Melanomas
title_fullStr Co‐expression of Thymidine Phosphorylase and Heme Oxygenase‐1 in Macrophages in Human Malignant Vertical Growth Melanomas
title_full_unstemmed Co‐expression of Thymidine Phosphorylase and Heme Oxygenase‐1 in Macrophages in Human Malignant Vertical Growth Melanomas
title_short Co‐expression of Thymidine Phosphorylase and Heme Oxygenase‐1 in Macrophages in Human Malignant Vertical Growth Melanomas
title_sort co‐expression of thymidine phosphorylase and heme oxygenase‐1 in macrophages in human malignant vertical growth melanomas
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926440/
https://www.ncbi.nlm.nih.gov/pubmed/11011118
http://dx.doi.org/10.1111/j.1349-7006.2000.tb01033.x
work_keys_str_mv AT torisuitakurahitoe coexpressionofthymidinephosphorylaseandhemeoxygenase1inmacrophagesinhumanmalignantverticalgrowthmelanomas
AT furuemasutaka coexpressionofthymidinephosphorylaseandhemeoxygenase1inmacrophagesinhumanmalignantverticalgrowthmelanomas
AT kuwanomichihiko coexpressionofthymidinephosphorylaseandhemeoxygenase1inmacrophagesinhumanmalignantverticalgrowthmelanomas
AT onomayumi coexpressionofthymidinephosphorylaseandhemeoxygenase1inmacrophagesinhumanmalignantverticalgrowthmelanomas