Ginsenoside Rg5 prevents apoptosis by modulating heme-oxygenase-1/nuclear factor E2-related factor 2 signaling and alters the expression of cognitive impairment-associated genes in thermal stress-exposed HT22 cells

Our results suggested that thermal stress can lead to activation of hippocampal cell damage and reduction of memory-associated molecules in HT22 cells. These findings also provide a part of molecular rationale for the role of ginsenoside Rg5 as a potent cognitive impairment preventive compound in bl...

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Detalles Bibliográficos
Autores principales: Choi, Seo-Yun, Kim, Kui-Jin, Song, Ji-Hyeon, Lee, Boo-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926500/
https://www.ncbi.nlm.nih.gov/pubmed/29719470
http://dx.doi.org/10.1016/j.jgr.2017.02.002
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author Choi, Seo-Yun
Kim, Kui-Jin
Song, Ji-Hyeon
Lee, Boo-Yong
author_facet Choi, Seo-Yun
Kim, Kui-Jin
Song, Ji-Hyeon
Lee, Boo-Yong
author_sort Choi, Seo-Yun
collection PubMed
description Our results suggested that thermal stress can lead to activation of hippocampal cell damage and reduction of memory-associated molecules in HT22 cells. These findings also provide a part of molecular rationale for the role of ginsenoside Rg5 as a potent cognitive impairment preventive compound in blocking the initiation of hippocampal damage.
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spelling pubmed-59265002018-05-01 Ginsenoside Rg5 prevents apoptosis by modulating heme-oxygenase-1/nuclear factor E2-related factor 2 signaling and alters the expression of cognitive impairment-associated genes in thermal stress-exposed HT22 cells Choi, Seo-Yun Kim, Kui-Jin Song, Ji-Hyeon Lee, Boo-Yong J Ginseng Res Research Article Our results suggested that thermal stress can lead to activation of hippocampal cell damage and reduction of memory-associated molecules in HT22 cells. These findings also provide a part of molecular rationale for the role of ginsenoside Rg5 as a potent cognitive impairment preventive compound in blocking the initiation of hippocampal damage. Elsevier 2018-04 2017-02-28 /pmc/articles/PMC5926500/ /pubmed/29719470 http://dx.doi.org/10.1016/j.jgr.2017.02.002 Text en © 2017 The Korean Society of Ginseng, Published by Elsevier Korea LLC. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Choi, Seo-Yun
Kim, Kui-Jin
Song, Ji-Hyeon
Lee, Boo-Yong
Ginsenoside Rg5 prevents apoptosis by modulating heme-oxygenase-1/nuclear factor E2-related factor 2 signaling and alters the expression of cognitive impairment-associated genes in thermal stress-exposed HT22 cells
title Ginsenoside Rg5 prevents apoptosis by modulating heme-oxygenase-1/nuclear factor E2-related factor 2 signaling and alters the expression of cognitive impairment-associated genes in thermal stress-exposed HT22 cells
title_full Ginsenoside Rg5 prevents apoptosis by modulating heme-oxygenase-1/nuclear factor E2-related factor 2 signaling and alters the expression of cognitive impairment-associated genes in thermal stress-exposed HT22 cells
title_fullStr Ginsenoside Rg5 prevents apoptosis by modulating heme-oxygenase-1/nuclear factor E2-related factor 2 signaling and alters the expression of cognitive impairment-associated genes in thermal stress-exposed HT22 cells
title_full_unstemmed Ginsenoside Rg5 prevents apoptosis by modulating heme-oxygenase-1/nuclear factor E2-related factor 2 signaling and alters the expression of cognitive impairment-associated genes in thermal stress-exposed HT22 cells
title_short Ginsenoside Rg5 prevents apoptosis by modulating heme-oxygenase-1/nuclear factor E2-related factor 2 signaling and alters the expression of cognitive impairment-associated genes in thermal stress-exposed HT22 cells
title_sort ginsenoside rg5 prevents apoptosis by modulating heme-oxygenase-1/nuclear factor e2-related factor 2 signaling and alters the expression of cognitive impairment-associated genes in thermal stress-exposed ht22 cells
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926500/
https://www.ncbi.nlm.nih.gov/pubmed/29719470
http://dx.doi.org/10.1016/j.jgr.2017.02.002
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