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Current Methods for Skeletal Muscle Tissue Repair and Regeneration
Skeletal muscle has the capacity of regeneration after injury. However, for large volumes of muscle loss, this regeneration needs interventional support. Consequently, muscle injury provides an ongoing reconstructive and regenerative challenge in clinical work. To promote muscle repair and regenerat...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926523/ https://www.ncbi.nlm.nih.gov/pubmed/29850487 http://dx.doi.org/10.1155/2018/1984879 |
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author | Liu, Juan Saul, Dominik Böker, Kai Oliver Ernst, Jennifer Lehman, Wolfgang Schilling, Arndt F. |
author_facet | Liu, Juan Saul, Dominik Böker, Kai Oliver Ernst, Jennifer Lehman, Wolfgang Schilling, Arndt F. |
author_sort | Liu, Juan |
collection | PubMed |
description | Skeletal muscle has the capacity of regeneration after injury. However, for large volumes of muscle loss, this regeneration needs interventional support. Consequently, muscle injury provides an ongoing reconstructive and regenerative challenge in clinical work. To promote muscle repair and regeneration, different strategies have been developed within the last century and especially during the last few decades, including surgical techniques, physical therapy, biomaterials, and muscular tissue engineering as well as cell therapy. Still, there is a great need to develop new methods and materials, which promote skeletal muscle repair and functional regeneration. In this review, we give a comprehensive overview over the epidemiology of muscle tissue loss, highlight current strategies in clinical treatment, and discuss novel methods for muscle regeneration and challenges for their future clinical translation. |
format | Online Article Text |
id | pubmed-5926523 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-59265232018-05-30 Current Methods for Skeletal Muscle Tissue Repair and Regeneration Liu, Juan Saul, Dominik Böker, Kai Oliver Ernst, Jennifer Lehman, Wolfgang Schilling, Arndt F. Biomed Res Int Review Article Skeletal muscle has the capacity of regeneration after injury. However, for large volumes of muscle loss, this regeneration needs interventional support. Consequently, muscle injury provides an ongoing reconstructive and regenerative challenge in clinical work. To promote muscle repair and regeneration, different strategies have been developed within the last century and especially during the last few decades, including surgical techniques, physical therapy, biomaterials, and muscular tissue engineering as well as cell therapy. Still, there is a great need to develop new methods and materials, which promote skeletal muscle repair and functional regeneration. In this review, we give a comprehensive overview over the epidemiology of muscle tissue loss, highlight current strategies in clinical treatment, and discuss novel methods for muscle regeneration and challenges for their future clinical translation. Hindawi 2018-04-16 /pmc/articles/PMC5926523/ /pubmed/29850487 http://dx.doi.org/10.1155/2018/1984879 Text en Copyright © 2018 Juan Liu et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Liu, Juan Saul, Dominik Böker, Kai Oliver Ernst, Jennifer Lehman, Wolfgang Schilling, Arndt F. Current Methods for Skeletal Muscle Tissue Repair and Regeneration |
title | Current Methods for Skeletal Muscle Tissue Repair and Regeneration |
title_full | Current Methods for Skeletal Muscle Tissue Repair and Regeneration |
title_fullStr | Current Methods for Skeletal Muscle Tissue Repair and Regeneration |
title_full_unstemmed | Current Methods for Skeletal Muscle Tissue Repair and Regeneration |
title_short | Current Methods for Skeletal Muscle Tissue Repair and Regeneration |
title_sort | current methods for skeletal muscle tissue repair and regeneration |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926523/ https://www.ncbi.nlm.nih.gov/pubmed/29850487 http://dx.doi.org/10.1155/2018/1984879 |
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