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Complete resolution of extensive thrombosis of atheromatous non-aneurysmal descending aorta and pulmonary embolism with warfarin therapy

A 54-year-old man underwent decompressive craniectomy following a stroke. He further developed right lower limb ischaemia, and CT aortography revealed extensive aortic atherosclerotic disease. Urgent embolectomy prevented him from having a major amputation. He subsequently developed pulmonary emboli...

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Autores principales: Pande, Shrikant D, Kum, Steven, Safdar Husain, Farah, Kerner, Vishaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926604/
https://www.ncbi.nlm.nih.gov/pubmed/29703832
http://dx.doi.org/10.1136/bcr-2017-222715
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author Pande, Shrikant D
Kum, Steven
Safdar Husain, Farah
Kerner, Vishaka
author_facet Pande, Shrikant D
Kum, Steven
Safdar Husain, Farah
Kerner, Vishaka
author_sort Pande, Shrikant D
collection PubMed
description A 54-year-old man underwent decompressive craniectomy following a stroke. He further developed right lower limb ischaemia, and CT aortography revealed extensive aortic atherosclerotic disease. Urgent embolectomy prevented him from having a major amputation. He subsequently developed pulmonary embolism. This was initially treated with heparin followed by warfarin apart from antiplatelets and statin. A follow-up aortography at 3 months interval showed near complete resolution of atheromatous disease of the aorta. This report raises the possibility that apart from antiplatelets and lipid-lowering agents, anticoagulation may be responsible for resolution of such an extensive atheromatous disease and whether this can be considered as part of regular treatment.
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spelling pubmed-59266042018-05-01 Complete resolution of extensive thrombosis of atheromatous non-aneurysmal descending aorta and pulmonary embolism with warfarin therapy Pande, Shrikant D Kum, Steven Safdar Husain, Farah Kerner, Vishaka BMJ Case Rep Unexpected Outcome (Positive or Negative) Including Adverse Drug Reactions A 54-year-old man underwent decompressive craniectomy following a stroke. He further developed right lower limb ischaemia, and CT aortography revealed extensive aortic atherosclerotic disease. Urgent embolectomy prevented him from having a major amputation. He subsequently developed pulmonary embolism. This was initially treated with heparin followed by warfarin apart from antiplatelets and statin. A follow-up aortography at 3 months interval showed near complete resolution of atheromatous disease of the aorta. This report raises the possibility that apart from antiplatelets and lipid-lowering agents, anticoagulation may be responsible for resolution of such an extensive atheromatous disease and whether this can be considered as part of regular treatment. BMJ Publishing Group 2018-04-27 /pmc/articles/PMC5926604/ /pubmed/29703832 http://dx.doi.org/10.1136/bcr-2017-222715 Text en © BMJ Publishing Group Ltd (unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
spellingShingle Unexpected Outcome (Positive or Negative) Including Adverse Drug Reactions
Pande, Shrikant D
Kum, Steven
Safdar Husain, Farah
Kerner, Vishaka
Complete resolution of extensive thrombosis of atheromatous non-aneurysmal descending aorta and pulmonary embolism with warfarin therapy
title Complete resolution of extensive thrombosis of atheromatous non-aneurysmal descending aorta and pulmonary embolism with warfarin therapy
title_full Complete resolution of extensive thrombosis of atheromatous non-aneurysmal descending aorta and pulmonary embolism with warfarin therapy
title_fullStr Complete resolution of extensive thrombosis of atheromatous non-aneurysmal descending aorta and pulmonary embolism with warfarin therapy
title_full_unstemmed Complete resolution of extensive thrombosis of atheromatous non-aneurysmal descending aorta and pulmonary embolism with warfarin therapy
title_short Complete resolution of extensive thrombosis of atheromatous non-aneurysmal descending aorta and pulmonary embolism with warfarin therapy
title_sort complete resolution of extensive thrombosis of atheromatous non-aneurysmal descending aorta and pulmonary embolism with warfarin therapy
topic Unexpected Outcome (Positive or Negative) Including Adverse Drug Reactions
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926604/
https://www.ncbi.nlm.nih.gov/pubmed/29703832
http://dx.doi.org/10.1136/bcr-2017-222715
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