Chitosan Induces Apoptosis via Caspase‐3 Activation in Bladder Tumor Cells

Recently, because of its low toxicity and biological effects, chitosan has been widely used in the medical and pharmaceutical fields, e.g., for nasal or oral delivery of peptide or polar drug delivery. Here, we report a growth‐inhibitory effect of chitosan on tumor cells. The growth inhibition was e...

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Detalles Bibliográficos
Autores principales: Hasegawa, Masumi, Yagi, Keiko, Iwakawa, Seigo, Hirai, Midori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2001
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926722/
https://www.ncbi.nlm.nih.gov/pubmed/11346469
http://dx.doi.org/10.1111/j.1349-7006.2001.tb01116.x
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author Hasegawa, Masumi
Yagi, Keiko
Iwakawa, Seigo
Hirai, Midori
author_facet Hasegawa, Masumi
Yagi, Keiko
Iwakawa, Seigo
Hirai, Midori
author_sort Hasegawa, Masumi
collection PubMed
description Recently, because of its low toxicity and biological effects, chitosan has been widely used in the medical and pharmaceutical fields, e.g., for nasal or oral delivery of peptide or polar drug delivery. Here, we report a growth‐inhibitory effect of chitosan on tumor cells. The growth inhibition was examined by WST‐1 colorimetric assay and cell counting. We also observed DNA fragmentation, which is characteristic of apoptosis, and elevated caspase‐3‐like activity in chitosan‐treated cancer cells. The findings suggest that chitosan may have potential value in cancer therapy.
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spelling pubmed-59267222018-05-11 Chitosan Induces Apoptosis via Caspase‐3 Activation in Bladder Tumor Cells Hasegawa, Masumi Yagi, Keiko Iwakawa, Seigo Hirai, Midori Jpn J Cancer Res Article Recently, because of its low toxicity and biological effects, chitosan has been widely used in the medical and pharmaceutical fields, e.g., for nasal or oral delivery of peptide or polar drug delivery. Here, we report a growth‐inhibitory effect of chitosan on tumor cells. The growth inhibition was examined by WST‐1 colorimetric assay and cell counting. We also observed DNA fragmentation, which is characteristic of apoptosis, and elevated caspase‐3‐like activity in chitosan‐treated cancer cells. The findings suggest that chitosan may have potential value in cancer therapy. Blackwell Publishing Ltd 2001-04 /pmc/articles/PMC5926722/ /pubmed/11346469 http://dx.doi.org/10.1111/j.1349-7006.2001.tb01116.x Text en
spellingShingle Article
Hasegawa, Masumi
Yagi, Keiko
Iwakawa, Seigo
Hirai, Midori
Chitosan Induces Apoptosis via Caspase‐3 Activation in Bladder Tumor Cells
title Chitosan Induces Apoptosis via Caspase‐3 Activation in Bladder Tumor Cells
title_full Chitosan Induces Apoptosis via Caspase‐3 Activation in Bladder Tumor Cells
title_fullStr Chitosan Induces Apoptosis via Caspase‐3 Activation in Bladder Tumor Cells
title_full_unstemmed Chitosan Induces Apoptosis via Caspase‐3 Activation in Bladder Tumor Cells
title_short Chitosan Induces Apoptosis via Caspase‐3 Activation in Bladder Tumor Cells
title_sort chitosan induces apoptosis via caspase‐3 activation in bladder tumor cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926722/
https://www.ncbi.nlm.nih.gov/pubmed/11346469
http://dx.doi.org/10.1111/j.1349-7006.2001.tb01116.x
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