Expression of gp34 (OX40 Ligand) and OX40 on Human T Cell Clones

gp34, which we previously cloned, is a ligand of OX40 (CD 134), a costimulatory molecule involved in T cell activation. To elucidate the role of human OX40/OX40L interaction, we examined the expression of gp34 (OX40L) and OX40 in normal human hematopoietic cells by using flow cytometry. OX40 express...

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Detalles Bibliográficos
Autores principales: Takasawa, Naruhiko, Ishii, Naoto, Higashimura, Norikazu, Murata, Kazuko, Tanaka, Yuetsu, Nakamura, Masataka, Sasaki, Takeshi, Sugamura, Kazuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2001
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926725/
https://www.ncbi.nlm.nih.gov/pubmed/11346458
http://dx.doi.org/10.1111/j.1349-7006.2001.tb01105.x
Descripción
Sumario:gp34, which we previously cloned, is a ligand of OX40 (CD 134), a costimulatory molecule involved in T cell activation. To elucidate the role of human OX40/OX40L interaction, we examined the expression of gp34 (OX40L) and OX40 in normal human hematopoietic cells by using flow cytometry. OX40 expression is observed on activated T cells, while OX40L is expressed in antigen‐presenting cells. However, cytotoxic T lymphocyte (CTL) clones specific for Epstein‐Barr virus (EBV)‐transformed autologous lymphoblastic cell lines (LCLs) induced both OX40 and OX40L expression after antigen or T cell receptor (TCR) stimulation. This study suggests a possible function of OX40L/OX40, through T cell‐T cell interaction, in the reactivation of memory T cells in an auto‐crine manner, with implications for the pathogenesis of viral infections and neoplasms.

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