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Expression of gp34 (OX40 Ligand) and OX40 on Human T Cell Clones

gp34, which we previously cloned, is a ligand of OX40 (CD 134), a costimulatory molecule involved in T cell activation. To elucidate the role of human OX40/OX40L interaction, we examined the expression of gp34 (OX40L) and OX40 in normal human hematopoietic cells by using flow cytometry. OX40 express...

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Autores principales: Takasawa, Naruhiko, Ishii, Naoto, Higashimura, Norikazu, Murata, Kazuko, Tanaka, Yuetsu, Nakamura, Masataka, Sasaki, Takeshi, Sugamura, Kazuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2001
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926725/
https://www.ncbi.nlm.nih.gov/pubmed/11346458
http://dx.doi.org/10.1111/j.1349-7006.2001.tb01105.x
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author Takasawa, Naruhiko
Ishii, Naoto
Higashimura, Norikazu
Murata, Kazuko
Tanaka, Yuetsu
Nakamura, Masataka
Sasaki, Takeshi
Sugamura, Kazuo
author_facet Takasawa, Naruhiko
Ishii, Naoto
Higashimura, Norikazu
Murata, Kazuko
Tanaka, Yuetsu
Nakamura, Masataka
Sasaki, Takeshi
Sugamura, Kazuo
author_sort Takasawa, Naruhiko
collection PubMed
description gp34, which we previously cloned, is a ligand of OX40 (CD 134), a costimulatory molecule involved in T cell activation. To elucidate the role of human OX40/OX40L interaction, we examined the expression of gp34 (OX40L) and OX40 in normal human hematopoietic cells by using flow cytometry. OX40 expression is observed on activated T cells, while OX40L is expressed in antigen‐presenting cells. However, cytotoxic T lymphocyte (CTL) clones specific for Epstein‐Barr virus (EBV)‐transformed autologous lymphoblastic cell lines (LCLs) induced both OX40 and OX40L expression after antigen or T cell receptor (TCR) stimulation. This study suggests a possible function of OX40L/OX40, through T cell‐T cell interaction, in the reactivation of memory T cells in an auto‐crine manner, with implications for the pathogenesis of viral infections and neoplasms.
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spelling pubmed-59267252018-05-11 Expression of gp34 (OX40 Ligand) and OX40 on Human T Cell Clones Takasawa, Naruhiko Ishii, Naoto Higashimura, Norikazu Murata, Kazuko Tanaka, Yuetsu Nakamura, Masataka Sasaki, Takeshi Sugamura, Kazuo Jpn J Cancer Res Article gp34, which we previously cloned, is a ligand of OX40 (CD 134), a costimulatory molecule involved in T cell activation. To elucidate the role of human OX40/OX40L interaction, we examined the expression of gp34 (OX40L) and OX40 in normal human hematopoietic cells by using flow cytometry. OX40 expression is observed on activated T cells, while OX40L is expressed in antigen‐presenting cells. However, cytotoxic T lymphocyte (CTL) clones specific for Epstein‐Barr virus (EBV)‐transformed autologous lymphoblastic cell lines (LCLs) induced both OX40 and OX40L expression after antigen or T cell receptor (TCR) stimulation. This study suggests a possible function of OX40L/OX40, through T cell‐T cell interaction, in the reactivation of memory T cells in an auto‐crine manner, with implications for the pathogenesis of viral infections and neoplasms. Blackwell Publishing Ltd 2001-04 /pmc/articles/PMC5926725/ /pubmed/11346458 http://dx.doi.org/10.1111/j.1349-7006.2001.tb01105.x Text en
spellingShingle Article
Takasawa, Naruhiko
Ishii, Naoto
Higashimura, Norikazu
Murata, Kazuko
Tanaka, Yuetsu
Nakamura, Masataka
Sasaki, Takeshi
Sugamura, Kazuo
Expression of gp34 (OX40 Ligand) and OX40 on Human T Cell Clones
title Expression of gp34 (OX40 Ligand) and OX40 on Human T Cell Clones
title_full Expression of gp34 (OX40 Ligand) and OX40 on Human T Cell Clones
title_fullStr Expression of gp34 (OX40 Ligand) and OX40 on Human T Cell Clones
title_full_unstemmed Expression of gp34 (OX40 Ligand) and OX40 on Human T Cell Clones
title_short Expression of gp34 (OX40 Ligand) and OX40 on Human T Cell Clones
title_sort expression of gp34 (ox40 ligand) and ox40 on human t cell clones
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926725/
https://www.ncbi.nlm.nih.gov/pubmed/11346458
http://dx.doi.org/10.1111/j.1349-7006.2001.tb01105.x
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