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CPT‐11 Alters the Circadian Rhythm of Dihydropyrimidine Dehydrogenase mRNA in Mouse Liver

Combination chemotherapy consisting of 5‐fluorouracil (5‐FU) and 7‐ethyl‐10‐[4‐(l‐piperidino)‐l‐piperidino]carboxycamptothecin (CPT‐11) is a promising regimen for gastrointestinal cancer. The circadian‐dependent efficacy and toxicity of 5‐FU are related to the circadian variation in the activity of...

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Detalles Bibliográficos
Autores principales:	Shimizu, Mikiko, Tamura, Tomohide, Yamada, Yasuhide, Akiyama, Yoshiko, Saijo, Nagahiro, Nishio, Kazuto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2001
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926738/ https://www.ncbi.nlm.nih.gov/pubmed/11376565 http://dx.doi.org/10.1111/j.1349-7006.2001.tb01129.x

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