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Expression of CYP2A6 in Tumor Cells Augments Cellular Sensitivity to Tegafur

To examine the role of cytochrome P450 2A6 (CYP2A6) in the cellular sensitivity to an anti‐tumor prodrug, tegafur (FT), a CYP2A6 cDNA construct was transfected into cells of a colon cancer cell line, DLD‐1. CYP2A6‐expressing cells (DLD‐1/CYP2A6 cells) more efficiently catalyzed the conversion of FT...

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Detalles Bibliográficos
Autores principales:	Murayama, Norie, Sai, Kimie, Nakajima, Yukiko, Kaniwa, Naoko, Ozawa, Shogo, Ohno, Yasuo, Sawada, Jun‐ichi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2001
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926740/ https://www.ncbi.nlm.nih.gov/pubmed/11376561 http://dx.doi.org/10.1111/j.1349-7006.2001.tb01125.x

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