The Antitumor Mechanism of 1‐(2‐Deoxy‐2‐fluoro‐4‐thio‐β‐D‐arabinofuranosyl)‐cytosine: Effects of Its Triphosphate on Mammalian DNA Polymerases

The mechanism of action of the antitumor nucleoside analog l‐(2‐deoxy‐2‐fluoro‐4‐thio‐β‐D‐arabinofuranosyl)cytosine (4′‐thio‐FAC) was investigated. 4′‐Thio‐FAC inhibited cellular DNA synthesis, but not RNA and protein syntheses. We observed potent inhibitory action of the triphosphate of 4′‐thio‐FAC...

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Detalles Bibliográficos
Autores principales: Miura, Shinji, Yoshimura, Yuichi, Satoh, Hiroshi, Izuta, Shunji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2001
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926742/
https://www.ncbi.nlm.nih.gov/pubmed/11376566
http://dx.doi.org/10.1111/j.1349-7006.2001.tb01130.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926742/
https://www.ncbi.nlm.nih.gov/pubmed/11376566
http://dx.doi.org/10.1111/j.1349-7006.2001.tb01130.x

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