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Hypophosphorylation of Topoisomerase IIα in Etoposide (VP‐16)‐resistant Human Carcinoma Cell Lines Associated with Carboxy‐terminal Truncation

Topoisomerase Ilα is a target for many chemotherapeutic agents in clinical use. To define mechanisms of resistance and regions crucial for the function of topoisomerase IIα, drug‐resistant cell lines have been isolated following exposure to topoisomerase II poisons. Two resistant sublines, T47D‐VP a...

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Detalles Bibliográficos
Autores principales:	Matsumoto, Yoshihito, Takano, Hiroshi, Kunishio, Katsuzo, Nagao, Seigo, Fojo, Tito
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2001
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926775/ https://www.ncbi.nlm.nih.gov/pubmed/11473732 http://dx.doi.org/10.1111/j.1349-7006.2001.tb01164.x

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