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Loss of KLHL6 promotes diffuse large B-cell lymphoma growth and survival by stabilizing the mRNA decay factor Roquin2

Kelch-like protein 6 (KLHL6) is an uncharacterized gene mutated in diffuse large B-cell lymphoma (DLBCL). We report that KLHL6 assembles with CULLIN3 to form a functional CULLIN-Ring ubiquitin ligase. Mutations of KLHL6 inhibit its ligase activity by disrupting the interaction with CULLIN3. Loss of...

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Detalles Bibliográficos
Autores principales: Choi, Jaewoo, Lee, Kyutae, Ingvarsdottir, Kristin, Bonasio, Roberto, Saraf, Anita, Florens, Laurence, Washburn, Michael P., Tadros, Saber, Green, Michael R., Busino, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926793/
https://www.ncbi.nlm.nih.gov/pubmed/29695787
http://dx.doi.org/10.1038/s41556-018-0084-5