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Glucose Intolerance, Plasma Insulin Levels, and Colon Adenomas in Japanese Men

Hyperinsulinemia may be related to colon carcinogenesis. Several studies have suggested that diabetes mellitus is related to increased risk of colon cancer. We examined cross‐sectionally the relation of fasting plasma insulin levels and glucose tolerance status to colon adenomas. In a consecutive se...

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Autores principales: Nishii, Takasei, Kono, Suminori, Abe, Hiroshi, Eguchi, Hiroyuki, Shimazaki, Kae, Hatano, Ben, Hamada, Hiroaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2001
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926827/
https://www.ncbi.nlm.nih.gov/pubmed/11509114
http://dx.doi.org/10.1111/j.1349-7006.2001.tb01169.x
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author Nishii, Takasei
Kono, Suminori
Abe, Hiroshi
Eguchi, Hiroyuki
Shimazaki, Kae
Hatano, Ben
Hamada, Hiroaki
author_facet Nishii, Takasei
Kono, Suminori
Abe, Hiroshi
Eguchi, Hiroyuki
Shimazaki, Kae
Hatano, Ben
Hamada, Hiroaki
author_sort Nishii, Takasei
collection PubMed
description Hyperinsulinemia may be related to colon carcinogenesis. Several studies have suggested that diabetes mellitus is related to increased risk of colon cancer. We examined cross‐sectionally the relation of fasting plasma insulin levels and glucose tolerance status to colon adenomas. In a consecutive series of 951 men undergoing total colonoscopy for a health examination at the Japan Self Defense Forces Fukuoka Hospital from April 1998 to August 1999, we identified 233 cases of colon adenomas and 497 controls with normal colonoscopy. Glucose tolerance status was determined by a 75‐g oral glucose tolerance test, and subjects were classified as normal, unpaired glucose tolerance (IGT) or non‐insulin dependent diabetes mellitus (NIDDM). Plasma insulin levels were measured after subjects had fasted overnight. Logistic regression analysis and analysis of covariance was used to control for age and obesity. While plasma insulin levels were unrelated to colon adenomas, NIDDM was associated with a significantly increased risk of colon adenomas. There was no association between IGT and colon adenomas. NIDDM was more strongly associated with proximal colon adenomas. The findings suggest that long‐term hyperinsulinemic status associated with NIDDM may increase the risk of colon adenomas, and subsequently of colon cancer.
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spelling pubmed-59268272018-05-11 Glucose Intolerance, Plasma Insulin Levels, and Colon Adenomas in Japanese Men Nishii, Takasei Kono, Suminori Abe, Hiroshi Eguchi, Hiroyuki Shimazaki, Kae Hatano, Ben Hamada, Hiroaki Jpn J Cancer Res Article Hyperinsulinemia may be related to colon carcinogenesis. Several studies have suggested that diabetes mellitus is related to increased risk of colon cancer. We examined cross‐sectionally the relation of fasting plasma insulin levels and glucose tolerance status to colon adenomas. In a consecutive series of 951 men undergoing total colonoscopy for a health examination at the Japan Self Defense Forces Fukuoka Hospital from April 1998 to August 1999, we identified 233 cases of colon adenomas and 497 controls with normal colonoscopy. Glucose tolerance status was determined by a 75‐g oral glucose tolerance test, and subjects were classified as normal, unpaired glucose tolerance (IGT) or non‐insulin dependent diabetes mellitus (NIDDM). Plasma insulin levels were measured after subjects had fasted overnight. Logistic regression analysis and analysis of covariance was used to control for age and obesity. While plasma insulin levels were unrelated to colon adenomas, NIDDM was associated with a significantly increased risk of colon adenomas. There was no association between IGT and colon adenomas. NIDDM was more strongly associated with proximal colon adenomas. The findings suggest that long‐term hyperinsulinemic status associated with NIDDM may increase the risk of colon adenomas, and subsequently of colon cancer. Blackwell Publishing Ltd 2001-08 /pmc/articles/PMC5926827/ /pubmed/11509114 http://dx.doi.org/10.1111/j.1349-7006.2001.tb01169.x Text en
spellingShingle Article
Nishii, Takasei
Kono, Suminori
Abe, Hiroshi
Eguchi, Hiroyuki
Shimazaki, Kae
Hatano, Ben
Hamada, Hiroaki
Glucose Intolerance, Plasma Insulin Levels, and Colon Adenomas in Japanese Men
title Glucose Intolerance, Plasma Insulin Levels, and Colon Adenomas in Japanese Men
title_full Glucose Intolerance, Plasma Insulin Levels, and Colon Adenomas in Japanese Men
title_fullStr Glucose Intolerance, Plasma Insulin Levels, and Colon Adenomas in Japanese Men
title_full_unstemmed Glucose Intolerance, Plasma Insulin Levels, and Colon Adenomas in Japanese Men
title_short Glucose Intolerance, Plasma Insulin Levels, and Colon Adenomas in Japanese Men
title_sort glucose intolerance, plasma insulin levels, and colon adenomas in japanese men
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926827/
https://www.ncbi.nlm.nih.gov/pubmed/11509114
http://dx.doi.org/10.1111/j.1349-7006.2001.tb01169.x
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