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Simultaneous Intraluminal Thermobrachytherapy: An in vitro Study

A multi‐institutional study on simultaneous intraluminal thermobrachytherapy (SITB) for advanced esophageal cancer was conducted in Japan. In this study, brachytherapy was administered by a small radioactive source stepping through a catheter in the esophagus, and hyperthermia was also applied by an...

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Detalles Bibliográficos
Autores principales: Furuta, Masaya, Tsukiyama, Iwao, Kano, Yasuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2001
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926832/
https://www.ncbi.nlm.nih.gov/pubmed/11509124
http://dx.doi.org/10.1111/j.1349-7006.2001.tb01179.x
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author Furuta, Masaya
Tsukiyama, Iwao
Kano, Yasuhiko
author_facet Furuta, Masaya
Tsukiyama, Iwao
Kano, Yasuhiko
author_sort Furuta, Masaya
collection PubMed
description A multi‐institutional study on simultaneous intraluminal thermobrachytherapy (SITB) for advanced esophageal cancer was conducted in Japan. In this study, brachytherapy was administered by a small radioactive source stepping through a catheter in the esophagus, and hyperthermia was also applied by an endoesophageal coil. However, experimental or clinical findings on the spatial distribution of its antitumor effects around the esophagus are not available. Therefore, we developed an in vitro model of SITB using a high‐dose‐rate iridium‐192 stepping source and two human cancer cell lines (WiDr and A549), and determined the spatial distribution of the antitumor effects. According to this model, the antitumor effects steeply decreased as the source‐cell distance increased when cells of both cell lines were irradiated with 5 Gy without heat. When WiDr cells, a more resistant cell line to radiation and heat, were simultaneously irradiated and heated for 30 min at 44°C, the effects decreased much less steeply as the distance increased. For A549 cells, a more sensitive cell line, irradiation with hyperthermia even at 42°C made the decrease in the effects smaller. The largest antitumor effects can be expected at 5‐10 mm beneath the esophageal mucosa, where the endoesophageal coil can heat tissues most effectively. SITE can induce larger antitumor effects than brachytherapy alone, especially in submucosal disease, which would favor treatment of advanced cancer.
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spelling pubmed-59268322018-05-11 Simultaneous Intraluminal Thermobrachytherapy: An in vitro Study Furuta, Masaya Tsukiyama, Iwao Kano, Yasuhiko Jpn J Cancer Res Article A multi‐institutional study on simultaneous intraluminal thermobrachytherapy (SITB) for advanced esophageal cancer was conducted in Japan. In this study, brachytherapy was administered by a small radioactive source stepping through a catheter in the esophagus, and hyperthermia was also applied by an endoesophageal coil. However, experimental or clinical findings on the spatial distribution of its antitumor effects around the esophagus are not available. Therefore, we developed an in vitro model of SITB using a high‐dose‐rate iridium‐192 stepping source and two human cancer cell lines (WiDr and A549), and determined the spatial distribution of the antitumor effects. According to this model, the antitumor effects steeply decreased as the source‐cell distance increased when cells of both cell lines were irradiated with 5 Gy without heat. When WiDr cells, a more resistant cell line to radiation and heat, were simultaneously irradiated and heated for 30 min at 44°C, the effects decreased much less steeply as the distance increased. For A549 cells, a more sensitive cell line, irradiation with hyperthermia even at 42°C made the decrease in the effects smaller. The largest antitumor effects can be expected at 5‐10 mm beneath the esophageal mucosa, where the endoesophageal coil can heat tissues most effectively. SITE can induce larger antitumor effects than brachytherapy alone, especially in submucosal disease, which would favor treatment of advanced cancer. Blackwell Publishing Ltd 2001-08 /pmc/articles/PMC5926832/ /pubmed/11509124 http://dx.doi.org/10.1111/j.1349-7006.2001.tb01179.x Text en
spellingShingle Article
Furuta, Masaya
Tsukiyama, Iwao
Kano, Yasuhiko
Simultaneous Intraluminal Thermobrachytherapy: An in vitro Study
title Simultaneous Intraluminal Thermobrachytherapy: An in vitro Study
title_full Simultaneous Intraluminal Thermobrachytherapy: An in vitro Study
title_fullStr Simultaneous Intraluminal Thermobrachytherapy: An in vitro Study
title_full_unstemmed Simultaneous Intraluminal Thermobrachytherapy: An in vitro Study
title_short Simultaneous Intraluminal Thermobrachytherapy: An in vitro Study
title_sort simultaneous intraluminal thermobrachytherapy: an in vitro study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926832/
https://www.ncbi.nlm.nih.gov/pubmed/11509124
http://dx.doi.org/10.1111/j.1349-7006.2001.tb01179.x
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