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Serum Copper/Zinc Superoxide Dismutase (Cu/Zn SOD) and Gastric Cancer Risk: a Case‐Control Study
We conducted a case‐control study to evaluate the association between serum levels of copper/zinc superoxide dismutase (Cu/Zn SOD) and the risk of gastric cancer. Cases were 214 patients who had been diagnosed with gastric cancer and controls were 120 persons who underwent medical checkups. Serum le...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2002
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926885/ https://www.ncbi.nlm.nih.gov/pubmed/12417035 http://dx.doi.org/10.1111/j.1349-7006.2002.tb01207.x |
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author | Lin, Yingsong Kikuchi, Shogo Obata, Yuki Yagyu, Kiyoko |
author_facet | Lin, Yingsong Kikuchi, Shogo Obata, Yuki Yagyu, Kiyoko |
author_sort | Lin, Yingsong |
collection | PubMed |
description | We conducted a case‐control study to evaluate the association between serum levels of copper/zinc superoxide dismutase (Cu/Zn SOD) and the risk of gastric cancer. Cases were 214 patients who had been diagnosed with gastric cancer and controls were 120 persons who underwent medical checkups. Serum levels of Cu/Zn SOD were determined by enzyme‐linked immunosorbent assay (ELISA). Compared with the lowest quartile, the OR (odds ratio) was 4.54 (95% CI (confidence interval), 1.62–12.66) for the third quartile and 15.75 (95% CI, 5.84–42.46) for the highest quartile. With both early and advanced cancers, as well as with the intestinal and diffuse types, a significant increase in risk was observed with increasing levels of serum Cu/Zn SOD. Our case‐control study showed that serum levels of Cu/Zn SOD were significantly elevated in gastric cancer patients compared with apparently healthy controls, and higher Cu/Zn SOD levels may be associated with an increased risk of gastric cancer. |
format | Online Article Text |
id | pubmed-5926885 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2002 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-59268852018-05-11 Serum Copper/Zinc Superoxide Dismutase (Cu/Zn SOD) and Gastric Cancer Risk: a Case‐Control Study Lin, Yingsong Kikuchi, Shogo Obata, Yuki Yagyu, Kiyoko Jpn J Cancer Res Rapid Communication We conducted a case‐control study to evaluate the association between serum levels of copper/zinc superoxide dismutase (Cu/Zn SOD) and the risk of gastric cancer. Cases were 214 patients who had been diagnosed with gastric cancer and controls were 120 persons who underwent medical checkups. Serum levels of Cu/Zn SOD were determined by enzyme‐linked immunosorbent assay (ELISA). Compared with the lowest quartile, the OR (odds ratio) was 4.54 (95% CI (confidence interval), 1.62–12.66) for the third quartile and 15.75 (95% CI, 5.84–42.46) for the highest quartile. With both early and advanced cancers, as well as with the intestinal and diffuse types, a significant increase in risk was observed with increasing levels of serum Cu/Zn SOD. Our case‐control study showed that serum levels of Cu/Zn SOD were significantly elevated in gastric cancer patients compared with apparently healthy controls, and higher Cu/Zn SOD levels may be associated with an increased risk of gastric cancer. Blackwell Publishing Ltd 2002-10 /pmc/articles/PMC5926885/ /pubmed/12417035 http://dx.doi.org/10.1111/j.1349-7006.2002.tb01207.x Text en |
spellingShingle | Rapid Communication Lin, Yingsong Kikuchi, Shogo Obata, Yuki Yagyu, Kiyoko Serum Copper/Zinc Superoxide Dismutase (Cu/Zn SOD) and Gastric Cancer Risk: a Case‐Control Study |
title | Serum Copper/Zinc Superoxide Dismutase (Cu/Zn SOD) and Gastric Cancer Risk: a Case‐Control Study |
title_full | Serum Copper/Zinc Superoxide Dismutase (Cu/Zn SOD) and Gastric Cancer Risk: a Case‐Control Study |
title_fullStr | Serum Copper/Zinc Superoxide Dismutase (Cu/Zn SOD) and Gastric Cancer Risk: a Case‐Control Study |
title_full_unstemmed | Serum Copper/Zinc Superoxide Dismutase (Cu/Zn SOD) and Gastric Cancer Risk: a Case‐Control Study |
title_short | Serum Copper/Zinc Superoxide Dismutase (Cu/Zn SOD) and Gastric Cancer Risk: a Case‐Control Study |
title_sort | serum copper/zinc superoxide dismutase (cu/zn sod) and gastric cancer risk: a case‐control study |
topic | Rapid Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926885/ https://www.ncbi.nlm.nih.gov/pubmed/12417035 http://dx.doi.org/10.1111/j.1349-7006.2002.tb01207.x |
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