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Identification of the CAB2/hCOS16 Gene Required for the Repair of DNA Double‐strand Breaks on a Core Amplified Region of the 17ql2 Locus in Breast and Gastric Cancers
We previously reported that CAB1 and c‐ERBB‐2 genes were found to be located in a core amplified region of the 17q12 locus, which is frequently amplified in various cancers. During identification of this core region, CAB2, a human homologue of the yeast COS16 required for the repair of DNA double‐st...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2002
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926894/ https://www.ncbi.nlm.nih.gov/pubmed/12460457 http://dx.doi.org/10.1111/j.1349-7006.2002.tb01221.x |
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author | Nezu, Masahiko Nishigaki, Michiko Ishizuka, Tomoki Kuwahara, Yoshitaka Tanabe, Chikako Aoyagi, Kazuhiko Sakamoto, Hiromi Saito, Yasushi Yoshida, Terahiko Sasaki, Hiroki Terada, Masaaki |
author_facet | Nezu, Masahiko Nishigaki, Michiko Ishizuka, Tomoki Kuwahara, Yoshitaka Tanabe, Chikako Aoyagi, Kazuhiko Sakamoto, Hiromi Saito, Yasushi Yoshida, Terahiko Sasaki, Hiroki Terada, Masaaki |
author_sort | Nezu, Masahiko |
collection | PubMed |
description | We previously reported that CAB1 and c‐ERBB‐2 genes were found to be located in a core amplified region of the 17q12 locus, which is frequently amplified in various cancers. During identification of this core region, CAB2, a human homologue of the yeast COS16 required for the repair of DNA double‐strand breaks was cloned. Autofluorescence analysis of cells transfected with its GFP fusion protein demonstrated that CAB2 translocates into vesicles, suggesting that overexpression of CAB2 may decrease intercellular Mn(2+) by accumulating it in the vesicles, in the same way as yeast COS16. This is the first report identifying all of the genes on the core amplified region of the 17q12 locus in breast and gastric cancers. |
format | Online Article Text |
id | pubmed-5926894 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2002 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-59268942018-05-11 Identification of the CAB2/hCOS16 Gene Required for the Repair of DNA Double‐strand Breaks on a Core Amplified Region of the 17ql2 Locus in Breast and Gastric Cancers Nezu, Masahiko Nishigaki, Michiko Ishizuka, Tomoki Kuwahara, Yoshitaka Tanabe, Chikako Aoyagi, Kazuhiko Sakamoto, Hiromi Saito, Yasushi Yoshida, Terahiko Sasaki, Hiroki Terada, Masaaki Jpn J Cancer Res Rapid Communication We previously reported that CAB1 and c‐ERBB‐2 genes were found to be located in a core amplified region of the 17q12 locus, which is frequently amplified in various cancers. During identification of this core region, CAB2, a human homologue of the yeast COS16 required for the repair of DNA double‐strand breaks was cloned. Autofluorescence analysis of cells transfected with its GFP fusion protein demonstrated that CAB2 translocates into vesicles, suggesting that overexpression of CAB2 may decrease intercellular Mn(2+) by accumulating it in the vesicles, in the same way as yeast COS16. This is the first report identifying all of the genes on the core amplified region of the 17q12 locus in breast and gastric cancers. Blackwell Publishing Ltd 2002-11 /pmc/articles/PMC5926894/ /pubmed/12460457 http://dx.doi.org/10.1111/j.1349-7006.2002.tb01221.x Text en |
spellingShingle | Rapid Communication Nezu, Masahiko Nishigaki, Michiko Ishizuka, Tomoki Kuwahara, Yoshitaka Tanabe, Chikako Aoyagi, Kazuhiko Sakamoto, Hiromi Saito, Yasushi Yoshida, Terahiko Sasaki, Hiroki Terada, Masaaki Identification of the CAB2/hCOS16 Gene Required for the Repair of DNA Double‐strand Breaks on a Core Amplified Region of the 17ql2 Locus in Breast and Gastric Cancers |
title | Identification of the CAB2/hCOS16 Gene Required for the Repair of DNA Double‐strand Breaks on a Core Amplified Region of the 17ql2 Locus in Breast and Gastric Cancers |
title_full | Identification of the CAB2/hCOS16 Gene Required for the Repair of DNA Double‐strand Breaks on a Core Amplified Region of the 17ql2 Locus in Breast and Gastric Cancers |
title_fullStr | Identification of the CAB2/hCOS16 Gene Required for the Repair of DNA Double‐strand Breaks on a Core Amplified Region of the 17ql2 Locus in Breast and Gastric Cancers |
title_full_unstemmed | Identification of the CAB2/hCOS16 Gene Required for the Repair of DNA Double‐strand Breaks on a Core Amplified Region of the 17ql2 Locus in Breast and Gastric Cancers |
title_short | Identification of the CAB2/hCOS16 Gene Required for the Repair of DNA Double‐strand Breaks on a Core Amplified Region of the 17ql2 Locus in Breast and Gastric Cancers |
title_sort | identification of the cab2/hcos16 gene required for the repair of dna double‐strand breaks on a core amplified region of the 17ql2 locus in breast and gastric cancers |
topic | Rapid Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926894/ https://www.ncbi.nlm.nih.gov/pubmed/12460457 http://dx.doi.org/10.1111/j.1349-7006.2002.tb01221.x |
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