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Identification of the CAB2/hCOS16 Gene Required for the Repair of DNA Double‐strand Breaks on a Core Amplified Region of the 17ql2 Locus in Breast and Gastric Cancers

We previously reported that CAB1 and c‐ERBB‐2 genes were found to be located in a core amplified region of the 17q12 locus, which is frequently amplified in various cancers. During identification of this core region, CAB2, a human homologue of the yeast COS16 required for the repair of DNA double‐st...

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Autores principales: Nezu, Masahiko, Nishigaki, Michiko, Ishizuka, Tomoki, Kuwahara, Yoshitaka, Tanabe, Chikako, Aoyagi, Kazuhiko, Sakamoto, Hiromi, Saito, Yasushi, Yoshida, Terahiko, Sasaki, Hiroki, Terada, Masaaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2002
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926894/
https://www.ncbi.nlm.nih.gov/pubmed/12460457
http://dx.doi.org/10.1111/j.1349-7006.2002.tb01221.x
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author Nezu, Masahiko
Nishigaki, Michiko
Ishizuka, Tomoki
Kuwahara, Yoshitaka
Tanabe, Chikako
Aoyagi, Kazuhiko
Sakamoto, Hiromi
Saito, Yasushi
Yoshida, Terahiko
Sasaki, Hiroki
Terada, Masaaki
author_facet Nezu, Masahiko
Nishigaki, Michiko
Ishizuka, Tomoki
Kuwahara, Yoshitaka
Tanabe, Chikako
Aoyagi, Kazuhiko
Sakamoto, Hiromi
Saito, Yasushi
Yoshida, Terahiko
Sasaki, Hiroki
Terada, Masaaki
author_sort Nezu, Masahiko
collection PubMed
description We previously reported that CAB1 and c‐ERBB‐2 genes were found to be located in a core amplified region of the 17q12 locus, which is frequently amplified in various cancers. During identification of this core region, CAB2, a human homologue of the yeast COS16 required for the repair of DNA double‐strand breaks was cloned. Autofluorescence analysis of cells transfected with its GFP fusion protein demonstrated that CAB2 translocates into vesicles, suggesting that overexpression of CAB2 may decrease intercellular Mn(2+) by accumulating it in the vesicles, in the same way as yeast COS16. This is the first report identifying all of the genes on the core amplified region of the 17q12 locus in breast and gastric cancers.
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spelling pubmed-59268942018-05-11 Identification of the CAB2/hCOS16 Gene Required for the Repair of DNA Double‐strand Breaks on a Core Amplified Region of the 17ql2 Locus in Breast and Gastric Cancers Nezu, Masahiko Nishigaki, Michiko Ishizuka, Tomoki Kuwahara, Yoshitaka Tanabe, Chikako Aoyagi, Kazuhiko Sakamoto, Hiromi Saito, Yasushi Yoshida, Terahiko Sasaki, Hiroki Terada, Masaaki Jpn J Cancer Res Rapid Communication We previously reported that CAB1 and c‐ERBB‐2 genes were found to be located in a core amplified region of the 17q12 locus, which is frequently amplified in various cancers. During identification of this core region, CAB2, a human homologue of the yeast COS16 required for the repair of DNA double‐strand breaks was cloned. Autofluorescence analysis of cells transfected with its GFP fusion protein demonstrated that CAB2 translocates into vesicles, suggesting that overexpression of CAB2 may decrease intercellular Mn(2+) by accumulating it in the vesicles, in the same way as yeast COS16. This is the first report identifying all of the genes on the core amplified region of the 17q12 locus in breast and gastric cancers. Blackwell Publishing Ltd 2002-11 /pmc/articles/PMC5926894/ /pubmed/12460457 http://dx.doi.org/10.1111/j.1349-7006.2002.tb01221.x Text en
spellingShingle Rapid Communication
Nezu, Masahiko
Nishigaki, Michiko
Ishizuka, Tomoki
Kuwahara, Yoshitaka
Tanabe, Chikako
Aoyagi, Kazuhiko
Sakamoto, Hiromi
Saito, Yasushi
Yoshida, Terahiko
Sasaki, Hiroki
Terada, Masaaki
Identification of the CAB2/hCOS16 Gene Required for the Repair of DNA Double‐strand Breaks on a Core Amplified Region of the 17ql2 Locus in Breast and Gastric Cancers
title Identification of the CAB2/hCOS16 Gene Required for the Repair of DNA Double‐strand Breaks on a Core Amplified Region of the 17ql2 Locus in Breast and Gastric Cancers
title_full Identification of the CAB2/hCOS16 Gene Required for the Repair of DNA Double‐strand Breaks on a Core Amplified Region of the 17ql2 Locus in Breast and Gastric Cancers
title_fullStr Identification of the CAB2/hCOS16 Gene Required for the Repair of DNA Double‐strand Breaks on a Core Amplified Region of the 17ql2 Locus in Breast and Gastric Cancers
title_full_unstemmed Identification of the CAB2/hCOS16 Gene Required for the Repair of DNA Double‐strand Breaks on a Core Amplified Region of the 17ql2 Locus in Breast and Gastric Cancers
title_short Identification of the CAB2/hCOS16 Gene Required for the Repair of DNA Double‐strand Breaks on a Core Amplified Region of the 17ql2 Locus in Breast and Gastric Cancers
title_sort identification of the cab2/hcos16 gene required for the repair of dna double‐strand breaks on a core amplified region of the 17ql2 locus in breast and gastric cancers
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926894/
https://www.ncbi.nlm.nih.gov/pubmed/12460457
http://dx.doi.org/10.1111/j.1349-7006.2002.tb01221.x
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