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Inactivation of O(6)‐Methylguanine‐DNA Methyltransferase in Human Lung Adenocarcinoma Relates to High‐grade Histology and Worse Prognosis among Smokers

To evaluate the significance of O(6)‐methylguanine‐DNA methyltransferase (MGMT) activity in the development of human lung adenocarcinoma (AC), we investigated promoter hypermethylation of the MGMTx gene by methylation‐specific PCR, and the expression of MGMT protein by immuno‐histochemistry in relat...

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Detalles Bibliográficos
Autores principales:	Hayashi, Hiroyuki, Yazawa, Takuya, Okudela, Koji, Nagai, Jun‐ichi, Ito, Takaaki, Kanisawa, Masayoshi, Kitamura, Hitoshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2002
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926947/ https://www.ncbi.nlm.nih.gov/pubmed/11856482 http://dx.doi.org/10.1111/j.1349-7006.2002.tb01257.x

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