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Expansion of Lung Vα14 NKT Cells by Administration of α‐Galactosylceramide‐pulsed Dendritic Cells
NKT cells, a novel murine lymphoid lineage bearing an invariant T cell receptor encoded by Vα14 and Jα281 gene segments, recognize a specific ligand glycolipid, α‐galactosylceramide (α‐GalCer) in a CDld‐dependent manner. Recent research has revealed that activated Vα14 NKT cells have dramatic antitu...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2002
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927009/ https://www.ncbi.nlm.nih.gov/pubmed/11985789 http://dx.doi.org/10.1111/j.1349-7006.2002.tb01270.x |
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author | Akutsu, Yasunori Nakayama, Toshinori Harada, Michishige Kawano, Tetsu Motohashi, Shinichiro Shimizu, Eiko Ito, Toshihiro Kamada, Noriaki Saito, Takeshi Matsubara, Hisahiro Miyazawa, Yukimasa Ochiai, Takenori Taniguchi, Masaru |
author_facet | Akutsu, Yasunori Nakayama, Toshinori Harada, Michishige Kawano, Tetsu Motohashi, Shinichiro Shimizu, Eiko Ito, Toshihiro Kamada, Noriaki Saito, Takeshi Matsubara, Hisahiro Miyazawa, Yukimasa Ochiai, Takenori Taniguchi, Masaru |
author_sort | Akutsu, Yasunori |
collection | PubMed |
description | NKT cells, a novel murine lymphoid lineage bearing an invariant T cell receptor encoded by Vα14 and Jα281 gene segments, recognize a specific ligand glycolipid, α‐galactosylceramide (α‐GalCer) in a CDld‐dependent manner. Recent research has revealed that activated Vα14 NKT cells have dramatic antitumor effects against a wide variety of tumor cell lines in vivo and in vitro. Here, we demonstrate strong in vivo antitumor effects brought about by treatment with α‐GalCer‐pulsed dendritic cells in comparison with in vitro‐activated Vα14 NKT cells. Furthermore, we show a significant expansion of endogenous Vα14 NKT cells in the lung following the administration of α‐GalCer‐pulsed dendritic cells. The feasibility of immunotherapy with α‐GalCer‐pulsed dendritic cells is discussed. |
format | Online Article Text |
id | pubmed-5927009 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2002 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-59270092018-05-11 Expansion of Lung Vα14 NKT Cells by Administration of α‐Galactosylceramide‐pulsed Dendritic Cells Akutsu, Yasunori Nakayama, Toshinori Harada, Michishige Kawano, Tetsu Motohashi, Shinichiro Shimizu, Eiko Ito, Toshihiro Kamada, Noriaki Saito, Takeshi Matsubara, Hisahiro Miyazawa, Yukimasa Ochiai, Takenori Taniguchi, Masaru Jpn J Cancer Res Article NKT cells, a novel murine lymphoid lineage bearing an invariant T cell receptor encoded by Vα14 and Jα281 gene segments, recognize a specific ligand glycolipid, α‐galactosylceramide (α‐GalCer) in a CDld‐dependent manner. Recent research has revealed that activated Vα14 NKT cells have dramatic antitumor effects against a wide variety of tumor cell lines in vivo and in vitro. Here, we demonstrate strong in vivo antitumor effects brought about by treatment with α‐GalCer‐pulsed dendritic cells in comparison with in vitro‐activated Vα14 NKT cells. Furthermore, we show a significant expansion of endogenous Vα14 NKT cells in the lung following the administration of α‐GalCer‐pulsed dendritic cells. The feasibility of immunotherapy with α‐GalCer‐pulsed dendritic cells is discussed. Blackwell Publishing Ltd 2002-04 /pmc/articles/PMC5927009/ /pubmed/11985789 http://dx.doi.org/10.1111/j.1349-7006.2002.tb01270.x Text en |
spellingShingle | Article Akutsu, Yasunori Nakayama, Toshinori Harada, Michishige Kawano, Tetsu Motohashi, Shinichiro Shimizu, Eiko Ito, Toshihiro Kamada, Noriaki Saito, Takeshi Matsubara, Hisahiro Miyazawa, Yukimasa Ochiai, Takenori Taniguchi, Masaru Expansion of Lung Vα14 NKT Cells by Administration of α‐Galactosylceramide‐pulsed Dendritic Cells |
title | Expansion of Lung Vα14 NKT Cells by Administration of α‐Galactosylceramide‐pulsed Dendritic Cells |
title_full | Expansion of Lung Vα14 NKT Cells by Administration of α‐Galactosylceramide‐pulsed Dendritic Cells |
title_fullStr | Expansion of Lung Vα14 NKT Cells by Administration of α‐Galactosylceramide‐pulsed Dendritic Cells |
title_full_unstemmed | Expansion of Lung Vα14 NKT Cells by Administration of α‐Galactosylceramide‐pulsed Dendritic Cells |
title_short | Expansion of Lung Vα14 NKT Cells by Administration of α‐Galactosylceramide‐pulsed Dendritic Cells |
title_sort | expansion of lung vα14 nkt cells by administration of α‐galactosylceramide‐pulsed dendritic cells |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927009/ https://www.ncbi.nlm.nih.gov/pubmed/11985789 http://dx.doi.org/10.1111/j.1349-7006.2002.tb01270.x |
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