Genetic Polymorphisms of the UDP‐Glucuronosyltransferase 1A7 Gene and Irinotecan Toxicity in Japanese Cancer Patients

Irinotecan often causes unpredictably severe, occasionally fatal, toxicity involving leukopenia or diarrhea. It is converted by carboxyesterase to an active metabolite, SN–38, which is further conjugated and detoxified to SN–38–glucuronide by UDP‐glucuronosyltransferase (UGT). We genotyped the UGT1A...

Descripción completa

Detalles Bibliográficos
Autores principales: Ando, Maki, Ando, Yuichi, Sekido, Yoshitaka, Ando, Masahiko, Shimokata, Kaoru, Hasegawa, Yoshinori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2002
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927033/
https://www.ncbi.nlm.nih.gov/pubmed/12036456
http://dx.doi.org/10.1111/j.1349-7006.2002.tb01295.x

Ejemplares similares

Ejemplares similares