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Critical limb ischemia: current challenges and future prospects

Critical limb ischemia (CLI) is considered the most severe pattern of peripheral artery disease. It is defined by the presence of chronic ischemic rest pain, ulceration or gangrene attributable to the occlusion of peripheral arterial vessels. It is associated with a high risk of major amputation, ca...

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Autores principales: Uccioli, Luigi, Meloni, Marco, Izzo, Valentina, Giurato, Laura, Merolla, Stefano, Gandini, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927064/
https://www.ncbi.nlm.nih.gov/pubmed/29731636
http://dx.doi.org/10.2147/VHRM.S125065
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author Uccioli, Luigi
Meloni, Marco
Izzo, Valentina
Giurato, Laura
Merolla, Stefano
Gandini, Roberto
author_facet Uccioli, Luigi
Meloni, Marco
Izzo, Valentina
Giurato, Laura
Merolla, Stefano
Gandini, Roberto
author_sort Uccioli, Luigi
collection PubMed
description Critical limb ischemia (CLI) is considered the most severe pattern of peripheral artery disease. It is defined by the presence of chronic ischemic rest pain, ulceration or gangrene attributable to the occlusion of peripheral arterial vessels. It is associated with a high risk of major amputation, cardiovascular events and death. In this review, we presented a complete overview about physiopathology, diagnosis and holistic management of CLI. Revascularization is the first-line treatment, but several challenging cases are not treatable by conventional techniques. Unconventional techniques for the treatment of complex below-the-knee arterial disease are described. Furthermore, the state-of-the-art on gene and cell therapy for the treatment of no-option patients is reported.
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spelling pubmed-59270642018-05-04 Critical limb ischemia: current challenges and future prospects Uccioli, Luigi Meloni, Marco Izzo, Valentina Giurato, Laura Merolla, Stefano Gandini, Roberto Vasc Health Risk Manag Review Critical limb ischemia (CLI) is considered the most severe pattern of peripheral artery disease. It is defined by the presence of chronic ischemic rest pain, ulceration or gangrene attributable to the occlusion of peripheral arterial vessels. It is associated with a high risk of major amputation, cardiovascular events and death. In this review, we presented a complete overview about physiopathology, diagnosis and holistic management of CLI. Revascularization is the first-line treatment, but several challenging cases are not treatable by conventional techniques. Unconventional techniques for the treatment of complex below-the-knee arterial disease are described. Furthermore, the state-of-the-art on gene and cell therapy for the treatment of no-option patients is reported. Dove Medical Press 2018-04-26 /pmc/articles/PMC5927064/ /pubmed/29731636 http://dx.doi.org/10.2147/VHRM.S125065 Text en © 2018 Uccioli et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Review
Uccioli, Luigi
Meloni, Marco
Izzo, Valentina
Giurato, Laura
Merolla, Stefano
Gandini, Roberto
Critical limb ischemia: current challenges and future prospects
title Critical limb ischemia: current challenges and future prospects
title_full Critical limb ischemia: current challenges and future prospects
title_fullStr Critical limb ischemia: current challenges and future prospects
title_full_unstemmed Critical limb ischemia: current challenges and future prospects
title_short Critical limb ischemia: current challenges and future prospects
title_sort critical limb ischemia: current challenges and future prospects
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927064/
https://www.ncbi.nlm.nih.gov/pubmed/29731636
http://dx.doi.org/10.2147/VHRM.S125065
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