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Physical inactivity is associated with decreased growth differentiation factor 11 in chronic obstructive pulmonary disease
BACKGROUND: Growth differentiation factor 11 (GDF11) is reported to possess anti-aging and rejuvenating effects, including muscle regeneration and to be highly expressed in skeletal muscle. Recently, we demonstrated that the levels of plasma GDF11 were decreased in COPD. However, the effect of decre...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927187/ https://www.ncbi.nlm.nih.gov/pubmed/29731621 http://dx.doi.org/10.2147/COPD.S157035 |
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author | Tanaka, Rie Sugiura, Hisatoshi Yamada, Mitsuhiro Ichikawa, Tomohiro Koarai, Akira Fujino, Naoya Yanagisawa, Satoru Onodera, Katsuhiro Numakura, Tadahisa Sato, Kei Kyogoku, Yorihiko Sano, Hirohito Yamanaka, Shun Okazaki, Tatsuma Tamada, Tsutomu Miura, Motohiko Takahashi, Tsuneyuki Ichinose, Masakazu |
author_facet | Tanaka, Rie Sugiura, Hisatoshi Yamada, Mitsuhiro Ichikawa, Tomohiro Koarai, Akira Fujino, Naoya Yanagisawa, Satoru Onodera, Katsuhiro Numakura, Tadahisa Sato, Kei Kyogoku, Yorihiko Sano, Hirohito Yamanaka, Shun Okazaki, Tatsuma Tamada, Tsutomu Miura, Motohiko Takahashi, Tsuneyuki Ichinose, Masakazu |
author_sort | Tanaka, Rie |
collection | PubMed |
description | BACKGROUND: Growth differentiation factor 11 (GDF11) is reported to possess anti-aging and rejuvenating effects, including muscle regeneration and to be highly expressed in skeletal muscle. Recently, we demonstrated that the levels of plasma GDF11 were decreased in COPD. However, the effect of decreased circulating GDF11 in the pathophysiology of COPD remains unknown. The aim of this study is to investigate the association between the plasma GDF11 levels and various clinical parameters in patients with COPD. PATIENTS AND METHODS: Eighteen ex-smokers as control subjects and 70 COPD patients participated in the current study. We measured the levels of plasma GDF11 using immunoblotting, lung function, physical activity using a triaxial accelerometer, quadriceps strength, exercise capacity, and systemic inflammatory markers. We investigated the association between the levels of plasma GDF11 and these clinical parameters. RESULTS: The levels of plasma GDF11 in the COPD patients had significant positive correlations with the data of lung function. Furthermore, the levels of plasma GDF11 were significantly correlated with the physical activity, quadriceps strength, and exercise capacity. Moreover, the levels of plasma GDF11 were significantly correlated with the data of inflammatory markers. Although various factors were related to GDF11, the multiple regression analysis showed that physical activity was significantly associated with the levels of plasma GDF11. CONCLUSION: Physical inactivity was significantly related to the decreased GDF11 levels in COPD, which might be useful for understanding the pathogenesis of COPD. Clarifying the relationships between the physical inactivity and GDF11 may reveal a potentially attractive therapeutic approach in COPD via increasing the plasma levels of GDF11. |
format | Online Article Text |
id | pubmed-5927187 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-59271872018-05-04 Physical inactivity is associated with decreased growth differentiation factor 11 in chronic obstructive pulmonary disease Tanaka, Rie Sugiura, Hisatoshi Yamada, Mitsuhiro Ichikawa, Tomohiro Koarai, Akira Fujino, Naoya Yanagisawa, Satoru Onodera, Katsuhiro Numakura, Tadahisa Sato, Kei Kyogoku, Yorihiko Sano, Hirohito Yamanaka, Shun Okazaki, Tatsuma Tamada, Tsutomu Miura, Motohiko Takahashi, Tsuneyuki Ichinose, Masakazu Int J Chron Obstruct Pulmon Dis Original Research BACKGROUND: Growth differentiation factor 11 (GDF11) is reported to possess anti-aging and rejuvenating effects, including muscle regeneration and to be highly expressed in skeletal muscle. Recently, we demonstrated that the levels of plasma GDF11 were decreased in COPD. However, the effect of decreased circulating GDF11 in the pathophysiology of COPD remains unknown. The aim of this study is to investigate the association between the plasma GDF11 levels and various clinical parameters in patients with COPD. PATIENTS AND METHODS: Eighteen ex-smokers as control subjects and 70 COPD patients participated in the current study. We measured the levels of plasma GDF11 using immunoblotting, lung function, physical activity using a triaxial accelerometer, quadriceps strength, exercise capacity, and systemic inflammatory markers. We investigated the association between the levels of plasma GDF11 and these clinical parameters. RESULTS: The levels of plasma GDF11 in the COPD patients had significant positive correlations with the data of lung function. Furthermore, the levels of plasma GDF11 were significantly correlated with the physical activity, quadriceps strength, and exercise capacity. Moreover, the levels of plasma GDF11 were significantly correlated with the data of inflammatory markers. Although various factors were related to GDF11, the multiple regression analysis showed that physical activity was significantly associated with the levels of plasma GDF11. CONCLUSION: Physical inactivity was significantly related to the decreased GDF11 levels in COPD, which might be useful for understanding the pathogenesis of COPD. Clarifying the relationships between the physical inactivity and GDF11 may reveal a potentially attractive therapeutic approach in COPD via increasing the plasma levels of GDF11. Dove Medical Press 2018-04-24 /pmc/articles/PMC5927187/ /pubmed/29731621 http://dx.doi.org/10.2147/COPD.S157035 Text en © Tanaka et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Tanaka, Rie Sugiura, Hisatoshi Yamada, Mitsuhiro Ichikawa, Tomohiro Koarai, Akira Fujino, Naoya Yanagisawa, Satoru Onodera, Katsuhiro Numakura, Tadahisa Sato, Kei Kyogoku, Yorihiko Sano, Hirohito Yamanaka, Shun Okazaki, Tatsuma Tamada, Tsutomu Miura, Motohiko Takahashi, Tsuneyuki Ichinose, Masakazu Physical inactivity is associated with decreased growth differentiation factor 11 in chronic obstructive pulmonary disease |
title | Physical inactivity is associated with decreased growth differentiation factor 11 in chronic obstructive pulmonary disease |
title_full | Physical inactivity is associated with decreased growth differentiation factor 11 in chronic obstructive pulmonary disease |
title_fullStr | Physical inactivity is associated with decreased growth differentiation factor 11 in chronic obstructive pulmonary disease |
title_full_unstemmed | Physical inactivity is associated with decreased growth differentiation factor 11 in chronic obstructive pulmonary disease |
title_short | Physical inactivity is associated with decreased growth differentiation factor 11 in chronic obstructive pulmonary disease |
title_sort | physical inactivity is associated with decreased growth differentiation factor 11 in chronic obstructive pulmonary disease |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927187/ https://www.ncbi.nlm.nih.gov/pubmed/29731621 http://dx.doi.org/10.2147/COPD.S157035 |
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