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Viral targeting of TFIIB impairs de novo polymerase II recruitment and affects antiviral immunity

Viruses have evolved a plethora of mechanisms to target host antiviral responses. Here, we propose a yet uncharacterized mechanism of immune regulation by the orthomyxovirus Thogoto virus (THOV) ML protein through engaging general transcription factor TFIIB. ML generates a TFIIB depleted nuclear env...

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Detalles Bibliográficos
Autores principales:	Haas, Darya A., Meiler, Arno, Geiger, Katharina, Vogt, Carola, Preuss, Ellen, Kochs, Georg, Pichlmair, Andreas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927403/ https://www.ncbi.nlm.nih.gov/pubmed/29709033 http://dx.doi.org/10.1371/journal.ppat.1006980

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