Development and characterization of carboxy-terminus specific monoclonal antibodies for understanding MUC16 cleavage in human ovarian cancer

MUC16 is overexpressed in ovarian cancer and plays important roles in invasion and metastasis. Previously described monoclonal antibodies against cell surface expressed MUC16 recognize the N-terminal tandemly repeated epitopes present in cancer antigen 125 (CA125). MUC16 is cleaved at a specific loc...

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Detalles Bibliográficos
Autores principales: Aithal, Abhijit, Junker, Wade M., Kshirsagar, Prakash, Das, Srustidhar, Kaur, Sukhwinder, Orzechowski, Catherine, Gautam, Shailendra Kumar, Jahan, Rahat, Sheinin, Yuri M., Lakshmanan, Imayavaramban, Ponnusamy, Moorthy P., Batra, Surinder K., Jain, Maneesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927449/
https://www.ncbi.nlm.nih.gov/pubmed/29708979
http://dx.doi.org/10.1371/journal.pone.0193907

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