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Association between Myeloperoxidase Levels and Risk of Insulin Resistance in Egyptian Obese Women

BACKGROUND: Myeloperoxidase (MPO) is an enzyme involved in the pathogenesis of several diseases. AIM: The current study aimed to investigate serum MPO levels in obese Egyptian women and assess its relation with insulin resistance (IR) and other biochemical risk parameters. METHODS: The study include...

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Autores principales: Zaki, Moushira, Basha, Walaa, Reyad, Hanaa, Mohamed, Ramy, Hassan, Naglaa, Kholousi, Shams
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Republic of Macedonia 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927491/
https://www.ncbi.nlm.nih.gov/pubmed/29731928
http://dx.doi.org/10.3889/oamjms.2018.164
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author Zaki, Moushira
Basha, Walaa
Reyad, Hanaa
Mohamed, Ramy
Hassan, Naglaa
Kholousi, Shams
author_facet Zaki, Moushira
Basha, Walaa
Reyad, Hanaa
Mohamed, Ramy
Hassan, Naglaa
Kholousi, Shams
author_sort Zaki, Moushira
collection PubMed
description BACKGROUND: Myeloperoxidase (MPO) is an enzyme involved in the pathogenesis of several diseases. AIM: The current study aimed to investigate serum MPO levels in obese Egyptian women and assess its relation with insulin resistance (IR) and other biochemical risk parameters. METHODS: The study included 80 obese women and 50 age-and-sex-matched healthy controls. Insulin resistance (IR) was evaluated by the Homeostasis Model Assessment-Insulin Resistance (HOMA-IR). Serum MPO, fasting glucose, insulin and blood lipids and anthropometry were measured. Obese cases were divided into three groups based on MPO tertiles. ROC analysis was performed to obtain the optimal cut-off values of MPO to predicate IR in obese women. RESULTS: The mean serum MPO was significantly higher in obese cases than controls. Cases in the highest MPO tertile had higher HOMA-IR, blood lipids and pressure levels compared with those in the lower tertile. The cutoff point of MPO was > 87.8 (ng/mL) and area under curves was 0.82 (p < 0.01) for diagnosis of IR. MPO levels were higher in obese Egyptian women than healthy controls. CONCLUSION: Elevation of MPO was associated with abnormal metabolic parameters. MPO might be used as an earlier biomarker for IR and metabolic disturbance in obese women.
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spelling pubmed-59274912018-05-04 Association between Myeloperoxidase Levels and Risk of Insulin Resistance in Egyptian Obese Women Zaki, Moushira Basha, Walaa Reyad, Hanaa Mohamed, Ramy Hassan, Naglaa Kholousi, Shams Open Access Maced J Med Sci Clinical Science BACKGROUND: Myeloperoxidase (MPO) is an enzyme involved in the pathogenesis of several diseases. AIM: The current study aimed to investigate serum MPO levels in obese Egyptian women and assess its relation with insulin resistance (IR) and other biochemical risk parameters. METHODS: The study included 80 obese women and 50 age-and-sex-matched healthy controls. Insulin resistance (IR) was evaluated by the Homeostasis Model Assessment-Insulin Resistance (HOMA-IR). Serum MPO, fasting glucose, insulin and blood lipids and anthropometry were measured. Obese cases were divided into three groups based on MPO tertiles. ROC analysis was performed to obtain the optimal cut-off values of MPO to predicate IR in obese women. RESULTS: The mean serum MPO was significantly higher in obese cases than controls. Cases in the highest MPO tertile had higher HOMA-IR, blood lipids and pressure levels compared with those in the lower tertile. The cutoff point of MPO was > 87.8 (ng/mL) and area under curves was 0.82 (p < 0.01) for diagnosis of IR. MPO levels were higher in obese Egyptian women than healthy controls. CONCLUSION: Elevation of MPO was associated with abnormal metabolic parameters. MPO might be used as an earlier biomarker for IR and metabolic disturbance in obese women. Republic of Macedonia 2018-04-06 /pmc/articles/PMC5927491/ /pubmed/29731928 http://dx.doi.org/10.3889/oamjms.2018.164 Text en Copyright: © 2018 Moushira Zaki, Walaa Basha, Hanaa Reyad, Ramy Mohamed, Naglaa Hassan, Shams Kholousib. http://creativecommons.org/licenses/CC BY-NC/4.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).
spellingShingle Clinical Science
Zaki, Moushira
Basha, Walaa
Reyad, Hanaa
Mohamed, Ramy
Hassan, Naglaa
Kholousi, Shams
Association between Myeloperoxidase Levels and Risk of Insulin Resistance in Egyptian Obese Women
title Association between Myeloperoxidase Levels and Risk of Insulin Resistance in Egyptian Obese Women
title_full Association between Myeloperoxidase Levels and Risk of Insulin Resistance in Egyptian Obese Women
title_fullStr Association between Myeloperoxidase Levels and Risk of Insulin Resistance in Egyptian Obese Women
title_full_unstemmed Association between Myeloperoxidase Levels and Risk of Insulin Resistance in Egyptian Obese Women
title_short Association between Myeloperoxidase Levels and Risk of Insulin Resistance in Egyptian Obese Women
title_sort association between myeloperoxidase levels and risk of insulin resistance in egyptian obese women
topic Clinical Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927491/
https://www.ncbi.nlm.nih.gov/pubmed/29731928
http://dx.doi.org/10.3889/oamjms.2018.164
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