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Association between Myeloperoxidase Levels and Risk of Insulin Resistance in Egyptian Obese Women
BACKGROUND: Myeloperoxidase (MPO) is an enzyme involved in the pathogenesis of several diseases. AIM: The current study aimed to investigate serum MPO levels in obese Egyptian women and assess its relation with insulin resistance (IR) and other biochemical risk parameters. METHODS: The study include...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Republic of Macedonia
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927491/ https://www.ncbi.nlm.nih.gov/pubmed/29731928 http://dx.doi.org/10.3889/oamjms.2018.164 |
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author | Zaki, Moushira Basha, Walaa Reyad, Hanaa Mohamed, Ramy Hassan, Naglaa Kholousi, Shams |
author_facet | Zaki, Moushira Basha, Walaa Reyad, Hanaa Mohamed, Ramy Hassan, Naglaa Kholousi, Shams |
author_sort | Zaki, Moushira |
collection | PubMed |
description | BACKGROUND: Myeloperoxidase (MPO) is an enzyme involved in the pathogenesis of several diseases. AIM: The current study aimed to investigate serum MPO levels in obese Egyptian women and assess its relation with insulin resistance (IR) and other biochemical risk parameters. METHODS: The study included 80 obese women and 50 age-and-sex-matched healthy controls. Insulin resistance (IR) was evaluated by the Homeostasis Model Assessment-Insulin Resistance (HOMA-IR). Serum MPO, fasting glucose, insulin and blood lipids and anthropometry were measured. Obese cases were divided into three groups based on MPO tertiles. ROC analysis was performed to obtain the optimal cut-off values of MPO to predicate IR in obese women. RESULTS: The mean serum MPO was significantly higher in obese cases than controls. Cases in the highest MPO tertile had higher HOMA-IR, blood lipids and pressure levels compared with those in the lower tertile. The cutoff point of MPO was > 87.8 (ng/mL) and area under curves was 0.82 (p < 0.01) for diagnosis of IR. MPO levels were higher in obese Egyptian women than healthy controls. CONCLUSION: Elevation of MPO was associated with abnormal metabolic parameters. MPO might be used as an earlier biomarker for IR and metabolic disturbance in obese women. |
format | Online Article Text |
id | pubmed-5927491 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Republic of Macedonia |
record_format | MEDLINE/PubMed |
spelling | pubmed-59274912018-05-04 Association between Myeloperoxidase Levels and Risk of Insulin Resistance in Egyptian Obese Women Zaki, Moushira Basha, Walaa Reyad, Hanaa Mohamed, Ramy Hassan, Naglaa Kholousi, Shams Open Access Maced J Med Sci Clinical Science BACKGROUND: Myeloperoxidase (MPO) is an enzyme involved in the pathogenesis of several diseases. AIM: The current study aimed to investigate serum MPO levels in obese Egyptian women and assess its relation with insulin resistance (IR) and other biochemical risk parameters. METHODS: The study included 80 obese women and 50 age-and-sex-matched healthy controls. Insulin resistance (IR) was evaluated by the Homeostasis Model Assessment-Insulin Resistance (HOMA-IR). Serum MPO, fasting glucose, insulin and blood lipids and anthropometry were measured. Obese cases were divided into three groups based on MPO tertiles. ROC analysis was performed to obtain the optimal cut-off values of MPO to predicate IR in obese women. RESULTS: The mean serum MPO was significantly higher in obese cases than controls. Cases in the highest MPO tertile had higher HOMA-IR, blood lipids and pressure levels compared with those in the lower tertile. The cutoff point of MPO was > 87.8 (ng/mL) and area under curves was 0.82 (p < 0.01) for diagnosis of IR. MPO levels were higher in obese Egyptian women than healthy controls. CONCLUSION: Elevation of MPO was associated with abnormal metabolic parameters. MPO might be used as an earlier biomarker for IR and metabolic disturbance in obese women. Republic of Macedonia 2018-04-06 /pmc/articles/PMC5927491/ /pubmed/29731928 http://dx.doi.org/10.3889/oamjms.2018.164 Text en Copyright: © 2018 Moushira Zaki, Walaa Basha, Hanaa Reyad, Ramy Mohamed, Naglaa Hassan, Shams Kholousib. http://creativecommons.org/licenses/CC BY-NC/4.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0). |
spellingShingle | Clinical Science Zaki, Moushira Basha, Walaa Reyad, Hanaa Mohamed, Ramy Hassan, Naglaa Kholousi, Shams Association between Myeloperoxidase Levels and Risk of Insulin Resistance in Egyptian Obese Women |
title | Association between Myeloperoxidase Levels and Risk of Insulin Resistance in Egyptian Obese Women |
title_full | Association between Myeloperoxidase Levels and Risk of Insulin Resistance in Egyptian Obese Women |
title_fullStr | Association between Myeloperoxidase Levels and Risk of Insulin Resistance in Egyptian Obese Women |
title_full_unstemmed | Association between Myeloperoxidase Levels and Risk of Insulin Resistance in Egyptian Obese Women |
title_short | Association between Myeloperoxidase Levels and Risk of Insulin Resistance in Egyptian Obese Women |
title_sort | association between myeloperoxidase levels and risk of insulin resistance in egyptian obese women |
topic | Clinical Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927491/ https://www.ncbi.nlm.nih.gov/pubmed/29731928 http://dx.doi.org/10.3889/oamjms.2018.164 |
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