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The Comparison of Olanzapine and Risperidone Treatment in Male Schizophrenic Patients using Positive and Negative Syndromes Scale (PANSS)

INTRODUCTION: The most common method to compare olanzapine and risperidone is by calculating the score of positive and negative syndromes scale (PANSS). However, there were some conflicting results mentioned from previous studies. AIM: This study aimed to compare the treatment of olanzapine and risp...

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Autores principales: Lestari, Endah Tri, Effendy, Elmeida, Amin, Mustafa Mahmud, Loebis, Bahagia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Republic of Macedonia 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927493/
https://www.ncbi.nlm.nih.gov/pubmed/29731930
http://dx.doi.org/10.3889/oamjms.2018.153
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author Lestari, Endah Tri
Effendy, Elmeida
Amin, Mustafa Mahmud
Loebis, Bahagia
author_facet Lestari, Endah Tri
Effendy, Elmeida
Amin, Mustafa Mahmud
Loebis, Bahagia
author_sort Lestari, Endah Tri
collection PubMed
description INTRODUCTION: The most common method to compare olanzapine and risperidone is by calculating the score of positive and negative syndromes scale (PANSS). However, there were some conflicting results mentioned from previous studies. AIM: This study aimed to compare the treatment of olanzapine and risperidone using PANSS, limited to only male patients receiving inpatient treatment to obtain more significant results. METHODS: The subjects of this study were male schizophrenic patients in the acute phase of treatment (N = 68) who were hospitalised at the Mental Hospital Prof. Dr M. Ildrem, Indonesia. These participants were divided into two groups and treated with different atypical antipsychotics (olanzapine, 20 mg/day [n = 34]; risperidone, 6 mg/day [n = 34]). The scores of PANSS from both groups were collected from pre-test and post-test after 6 -week treatment. RESULTS: The improvement of the schizophrenia symptoms measured by PANSS after 6 weeks showed significant differences in the scores of PANSS between the male patient groups treated with olanzapine and risperidone (p-value < 0.001). CONCLUSION: The group of olanzapine shows a higher improvement of the scores of PANSS than that the group of risperidone.
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spelling pubmed-59274932018-05-04 The Comparison of Olanzapine and Risperidone Treatment in Male Schizophrenic Patients using Positive and Negative Syndromes Scale (PANSS) Lestari, Endah Tri Effendy, Elmeida Amin, Mustafa Mahmud Loebis, Bahagia Open Access Maced J Med Sci Clinical Science INTRODUCTION: The most common method to compare olanzapine and risperidone is by calculating the score of positive and negative syndromes scale (PANSS). However, there were some conflicting results mentioned from previous studies. AIM: This study aimed to compare the treatment of olanzapine and risperidone using PANSS, limited to only male patients receiving inpatient treatment to obtain more significant results. METHODS: The subjects of this study were male schizophrenic patients in the acute phase of treatment (N = 68) who were hospitalised at the Mental Hospital Prof. Dr M. Ildrem, Indonesia. These participants were divided into two groups and treated with different atypical antipsychotics (olanzapine, 20 mg/day [n = 34]; risperidone, 6 mg/day [n = 34]). The scores of PANSS from both groups were collected from pre-test and post-test after 6 -week treatment. RESULTS: The improvement of the schizophrenia symptoms measured by PANSS after 6 weeks showed significant differences in the scores of PANSS between the male patient groups treated with olanzapine and risperidone (p-value < 0.001). CONCLUSION: The group of olanzapine shows a higher improvement of the scores of PANSS than that the group of risperidone. Republic of Macedonia 2018-04-12 /pmc/articles/PMC5927493/ /pubmed/29731930 http://dx.doi.org/10.3889/oamjms.2018.153 Text en Copyright: © 2018 Endah Tri Lestari, Elmeida Effendy, Mustafa Mahmud Amin, Bahagia Loebis. http://creativecommons.org/licenses/CC BY-NC/4.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).
spellingShingle Clinical Science
Lestari, Endah Tri
Effendy, Elmeida
Amin, Mustafa Mahmud
Loebis, Bahagia
The Comparison of Olanzapine and Risperidone Treatment in Male Schizophrenic Patients using Positive and Negative Syndromes Scale (PANSS)
title The Comparison of Olanzapine and Risperidone Treatment in Male Schizophrenic Patients using Positive and Negative Syndromes Scale (PANSS)
title_full The Comparison of Olanzapine and Risperidone Treatment in Male Schizophrenic Patients using Positive and Negative Syndromes Scale (PANSS)
title_fullStr The Comparison of Olanzapine and Risperidone Treatment in Male Schizophrenic Patients using Positive and Negative Syndromes Scale (PANSS)
title_full_unstemmed The Comparison of Olanzapine and Risperidone Treatment in Male Schizophrenic Patients using Positive and Negative Syndromes Scale (PANSS)
title_short The Comparison of Olanzapine and Risperidone Treatment in Male Schizophrenic Patients using Positive and Negative Syndromes Scale (PANSS)
title_sort comparison of olanzapine and risperidone treatment in male schizophrenic patients using positive and negative syndromes scale (panss)
topic Clinical Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927493/
https://www.ncbi.nlm.nih.gov/pubmed/29731930
http://dx.doi.org/10.3889/oamjms.2018.153
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