M7824, a novel bifunctional anti-PD-L1/TGFβ Trap fusion protein, promotes anti-tumor efficacy as monotherapy and in combination with vaccine

Tumors evade host immune surveillance through multiple mechanisms, including the generation of a tumor microenvironment that suppresses immune effector function. Secretion of TGFβ and upregulation of immune checkpoint programmed cell death ligand-1 (PD-L1) are two main contributors to immune evasion...

Descripción completa

Detalles Bibliográficos
Autores principales: Knudson, Karin M., Hicks, Kristin C., Luo, Xiaoling, Chen, Jin-Qiu, Schlom, Jeffrey, Gameiro, Sofia R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927523/
https://www.ncbi.nlm.nih.gov/pubmed/29721396
http://dx.doi.org/10.1080/2162402X.2018.1426519

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927523/
https://www.ncbi.nlm.nih.gov/pubmed/29721396
http://dx.doi.org/10.1080/2162402X.2018.1426519

Ejemplares similares