Complimentary mechanisms of dual checkpoint blockade expand unique T-cell repertoires and activate adaptive anti-tumor immunity in triple-negative breast tumors

Triple-negative breast cancer (TNBC) is an aggressive and molecularly diverse breast cancer subtype typified by the presence of p53 mutations (∼80%), elevated immune gene signatures and neoantigen expression, as well as the presence of tumor infiltrating lymphocytes (TILs). As these factors are hypo...

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Detalles Bibliográficos
Autores principales: Crosby, Erika J., Wei, Junping, Yang, Xiao Yi, Lei, Gangjun, Wang, Tao, Liu, Cong-Xiao, Agarwal, Pankaj, Korman, Alan J., Morse, Michael A., Gouin, Kenneth, Knott, Simon R. V., Lyerly, H. Kim, Hartman, Zachary C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927534/
https://www.ncbi.nlm.nih.gov/pubmed/29721371
http://dx.doi.org/10.1080/2162402X.2017.1421891

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