Microenvironment-Mediated Mechanisms of Resistance to HER2 Inhibitors Differ between HER2+ Breast Cancer Subtypes

Extrinsic signals are implicated in breast cancer resistance to HER2-targeted tyrosine kinase inhibitors (TKIs). To examine how microenvironmental signals influence resistance, we monitored TKI-treated breast cancer cell lines grown on microenvironment microarrays composed of printed extracellular m...

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Detalles Bibliográficos
Autores principales: Watson, Spencer S., Dane, Mark, Chin, Koei, Tatarova, Zuzana, Liu, Moqing, Liby, Tiera, Thompson, Wallace, Smith, Rebecca, Nederlof, Michel, Bucher, Elmar, Kilburn, David, Whitman, Matthew, Sudar, Damir, Mills, Gordon B., Heiser, Laura M., Jonas, Oliver, Gray, Joe W., Korkola, James E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927625/
https://www.ncbi.nlm.nih.gov/pubmed/29550255
http://dx.doi.org/10.1016/j.cels.2018.02.001

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