Orphan CpG islands as alternative promoters

CpG islands (CGIs) are associated with ∼60% of mammalian promoters. Most unmethylated CGIs exhibit transcriptional activity, which has led to their co-option as promoters by retrogenes. CGIs may also serve as alternative promoters for downstream genes with methylated promoters, with implications on...

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Detalles Bibliográficos
Autores principales: Sarda, Shrutii, Hannenhalli, Sridhar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Point-of-View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927659/
https://www.ncbi.nlm.nih.gov/pubmed/29099304
http://dx.doi.org/10.1080/21541264.2017.1373209
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author Sarda, Shrutii
Hannenhalli, Sridhar
author_facet Sarda, Shrutii
Hannenhalli, Sridhar
author_sort Sarda, Shrutii
collection PubMed
description CpG islands (CGIs) are associated with ∼60% of mammalian promoters. Most unmethylated CGIs exhibit transcriptional activity, which has led to their co-option as promoters by retrogenes. CGIs may also serve as alternative promoters for downstream genes with methylated promoters, with implications on aberrant activation of oncogenes in cancer phenotypes.
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spelling pubmed-59276592018-05-02 Orphan CpG islands as alternative promoters Sarda, Shrutii Hannenhalli, Sridhar Transcription Point-of-View CpG islands (CGIs) are associated with ∼60% of mammalian promoters. Most unmethylated CGIs exhibit transcriptional activity, which has led to their co-option as promoters by retrogenes. CGIs may also serve as alternative promoters for downstream genes with methylated promoters, with implications on aberrant activation of oncogenes in cancer phenotypes. Taylor & Francis 2017-11-28 /pmc/articles/PMC5927659/ /pubmed/29099304 http://dx.doi.org/10.1080/21541264.2017.1373209 Text en © 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Point-of-View
Sarda, Shrutii
Hannenhalli, Sridhar
Orphan CpG islands as alternative promoters
title Orphan CpG islands as alternative promoters
title_full Orphan CpG islands as alternative promoters
title_fullStr Orphan CpG islands as alternative promoters
title_full_unstemmed Orphan CpG islands as alternative promoters
title_short Orphan CpG islands as alternative promoters
title_sort orphan cpg islands as alternative promoters
topic Point-of-View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927659/
https://www.ncbi.nlm.nih.gov/pubmed/29099304
http://dx.doi.org/10.1080/21541264.2017.1373209
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