Cargando…

Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy

Despite their importance as signaling hubs, the function of mitochondria-ER contact sites in mitochondrial quality control pathways remains unexplored. Here we describe a mechanism by which Mfn2, a mitochondria-ER tether, gates the autophagic turnover of mitochondria by PINK1 and parkin. Mitochondri...

Descripción completa

Detalles Bibliográficos
Autores principales:	McLelland, Gian-Luca, Goiran, Thomas, Yi, Wei, Dorval, Geneviève, Chen, Carol X, Lauinger, Nadine D, Krahn, Andrea I, Valimehr, Sepideh, Rakovic, Aleksandar, Rouiller, Isabelle, Durcan, Thomas M, Trempe, Jean-François, Fon, Edward A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2018
Materias:	Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927771/ https://www.ncbi.nlm.nih.gov/pubmed/29676259 http://dx.doi.org/10.7554/eLife.32866

Ejemplares similares

Parkin- and PINK1-Dependent Mitophagy in Neurons: Will the Real Pathway Please Stand Up?
por: Grenier, Karl, et al.
Publicado: (2013)

Selective localization of Mfn2 near PINK1 enables its preferential ubiquitination by Parkin on mitochondria
por: Vranas, Marta, et al.
Publicado: (2022)

The three ‘P’s of mitophagy: PARKIN, PINK1, and post-translational modifications
por: Durcan, Thomas M., et al.
Publicado: (2015)

Syntaxin-17 delivers PINK1/parkin-dependent mitochondrial vesicles to the endolysosomal system
por: McLelland, Gian-Luca, et al.
Publicado: (2016)

Structure and Function of Parkin, PINK1, and DJ-1, the Three Musketeers of Neuroprotection
por: Trempe, Jean-François, et al.
Publicado: (2013)

Mitophagy and Parkinson's disease: The PINK1–parkin link()
por: Deas, Emma, et al.
Publicado: (2011)

Mutations in PINK1 and Parkin Impair Ubiquitination of Mitofusins in Human Fibroblasts
por: Rakovic, Aleksandar, et al.
Publicado: (2011)

Loss of iron triggers PINK1/Parkin-independent mitophagy
por: Allen, George F G, et al.
Publicado: (2013)

Molecular Mechanisms Driving and Regulating the AAA+ ATPase VCP/p97, an Important Therapeutic Target for Treating Cancer, Neurological and Infectious Diseases
por: Valimehr, Sepideh, et al.
Publicado: (2023)

Superoxide drives progression of Parkin/PINK1-dependent mitophagy following translocation of Parkin to mitochondria
por: Xiao, Bin, et al.
Publicado: (2017)

Deficiency of parkin and PINK1 impairs age-dependent mitophagy in Drosophila
por: Cornelissen, Tom, et al.
Publicado: (2018)

PINK1-parkin-mediated neuronal mitophagy deficiency in prion disease
por: Li, Jie, et al.
Publicado: (2022)

Inhibition of mitoNEET induces Pink1-Parkin-mediated mitophagy
por: Lee, Seunghee, et al.
Publicado: (2022)

Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin
por: Tanaka, Atsushi, et al.
Publicado: (2010)

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy
por: Matsuda, Noriyuki, et al.
Publicado: (2010)

Correction: Superoxide drives progression of Parkin/PINK1-dependent mitophagy following translocation of Parkin to mitochondria
por: Xiao, Bin, et al.
Publicado: (2018)

PINK1 Is Dispensable for Mitochondrial Recruitment of Parkin and Activation of Mitophagy in Cardiac Myocytes
por: Kubli, Dieter A., et al.
Publicado: (2015)

Mitochondrial and lysosomal biogenesis are activated following PINK1/parkin‐mediated mitophagy
por: Ivankovic, Davor, et al.
Publicado: (2015)

Basal mitophagy is widespread in Drosophila but minimally affected by loss of Pink1 or parkin
por: Lee, Juliette J., et al.
Publicado: (2018)

Salidroside Protects Dopaminergic Neurons by Enhancing PINK1/Parkin-Mediated Mitophagy
por: Li, Ruru, et al.
Publicado: (2019)

PINK1/Parkin-mediated mitophagy in mechanical ventilation-induced diaphragmatic dysfunction
por: Yong, Hui, et al.
Publicado: (2021)

Cannabidiol activates PINK1-Parkin-dependent mitophagy and mitochondrial-derived vesicles
por: Ramirez, Adrian, et al.
Publicado: (2022)

Erythropoietin Mitigates Diabetic Nephropathy by Restoring PINK1/Parkin-Mediated Mitophagy
por: Yi, Xinyao, et al.
Publicado: (2022)

DJ-1 is an essential downstream mediator in PINK1/parkin-dependent mitophagy
por: Imberechts, Dorien, et al.
Publicado: (2022)

PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy
por: Shiba-Fukushima, Kahori, et al.
Publicado: (2012)

Mitophagy of damaged mitochondria occurs locally in distal neuronal axons and requires PINK1 and Parkin
por: Ashrafi, Ghazaleh, et al.
Publicado: (2014)

Structure-guided mutagenesis reveals a hierarchical mechanism of Parkin activation
por: Tang, Matthew Y., et al.
Publicado: (2017)

Bcl-2-associated athanogene 5 (BAG5) regulates Parkin-dependent mitophagy and cell death
por: De Snoo, Mitchell L., et al.
Publicado: (2019)

Morphological and bioenergetic demands underlying the mitophagy in post-mitotic neurons: the pink–parkin pathway
por: Amadoro, Giuseppina, et al.
Publicado: (2014)

Regulatory Roles of PINK1-Parkin and AMPK in Ubiquitin-Dependent Skeletal Muscle Mitophagy
por: Seabright, Alex P., et al.
Publicado: (2020)

The PINK1—Parkin mitophagy signalling pathway is not functional in peripheral blood mononuclear cells
por: Bradshaw, Aaron V., et al.
Publicado: (2021)

PINK1/Parkin‐mediated mitophagy enhances the survival of Staphylococcus aureus in bovine macrophages
por: Zhou, Xi, et al.
Publicado: (2023)

NDP52 acts as a redox sensor in PINK1/Parkin‐mediated mitophagy
por: Kataura, Tetsushi, et al.
Publicado: (2022)

A PINK1 input threshold arises from positive feedback in the PINK1/Parkin mitophagy decision circuit
por: Waters, Christopher S., et al.
Publicado: (2023)

Vanillic acid attenuates H(2)O(2)-induced injury in H9c2 cells by regulating mitophagy via the PINK1/Parkin/Mfn2 signaling pathway
por: Mei, Manxue, et al.
Publicado: (2022)

Structure-based design and characterization of Parkin-activating mutations
por: Stevens, Michael U, et al.
Publicado: (2023)

Counteracting PINK/Parkin Deficiency in the Activation of Mitophagy: A Potential Therapeutic Intervention for Parkinson’s Disease
por: Nardin, Alice, et al.
Publicado: (2016)

ATM mediates spermidine-induced mitophagy via PINK1 and Parkin regulation in human fibroblasts
por: Qi, Yongmei, et al.
Publicado: (2016)

Albumin Overload and PINK1/Parkin Signaling-Related Mitophagy in Renal Tubular Epithelial Cells
por: Tan, Jin, et al.
Publicado: (2018)

PINK1/Parkin-mediated mitophagy is activated in cisplatin nephrotoxicity to protect against kidney injury
por: Wang, Ying, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_h4igf79a1r1q0m1ukfjj34497a