Isoxazol-5(2H)-one: a new scaffold for potent human neutrophil elastase (HNE) inhibitors

Human neutrophil elastase (HNE) is an important target for the development of novel and selective inhibitors to treat inflammatory diseases, especially pulmonary pathologies. Here, we report the synthesis, structure–activity relationship analysis, and biological evaluation of a new series of HNE inh...

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Detalles Bibliográficos
Autores principales: Vergelli, Claudia, Schepetkin, Igor A., Crocetti, Letizia, Iacovone, Antonella, Giovannoni, Maria Paola, Guerrini, Gabriella, Khlebnikov, Andrei I., Ciattini, Samuele, Ciciani, Giovanna, Quinn, Mark T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Reasearch Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927774/
https://www.ncbi.nlm.nih.gov/pubmed/28612630
http://dx.doi.org/10.1080/14756366.2017.1326915

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927774/
https://www.ncbi.nlm.nih.gov/pubmed/28612630
http://dx.doi.org/10.1080/14756366.2017.1326915

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