Cargando…

Impact of extramedullary disease in patients with newly diagnosed multiple myeloma undergoing autologous stem cell transplantation: a study from the Chronic Malignancies Working Party of the EBMT

We investigated extramedullary disease in newly diagnosed multiple myeloma patients and its impact on outcome following first-line autologous stem cell transplantation. We identified 3744 adult myeloma patients who received up-front single (n=3391) or tandem transplantation (n=353) between 2005 and...

Descripción completa

Detalles Bibliográficos
Autores principales: Gagelmann, Nico, Eikema, Diderik-Jan, Iacobelli, Simona, Koster, Linda, Nahi, Hareth, Stoppa, Anne-Marie, Masszi, Tamás, Caillot, Denis, Lenhoff, Stig, Udvardy, Miklos, Crawley, Charles, Arcese, William, Mariette, Clara, Hunter, Ann, Leleu, Xavier, Schipperus, Martin, Delforge, Michel, Pioltelli, Pietro, Snowden, John A., Itälä-Remes, Maija, Musso, Maurizio, van Biezen, Anja, Garderet, Laurent, Kröger, Nicolaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ferrata Storti Foundation 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927971/
https://www.ncbi.nlm.nih.gov/pubmed/29419433
http://dx.doi.org/10.3324/haematol.2017.178434
_version_ 1783319148434030592
author Gagelmann, Nico
Eikema, Diderik-Jan
Iacobelli, Simona
Koster, Linda
Nahi, Hareth
Stoppa, Anne-Marie
Masszi, Tamás
Caillot, Denis
Lenhoff, Stig
Udvardy, Miklos
Crawley, Charles
Arcese, William
Mariette, Clara
Hunter, Ann
Leleu, Xavier
Schipperus, Martin
Delforge, Michel
Pioltelli, Pietro
Snowden, John A.
Itälä-Remes, Maija
Musso, Maurizio
van Biezen, Anja
Garderet, Laurent
Kröger, Nicolaus
author_facet Gagelmann, Nico
Eikema, Diderik-Jan
Iacobelli, Simona
Koster, Linda
Nahi, Hareth
Stoppa, Anne-Marie
Masszi, Tamás
Caillot, Denis
Lenhoff, Stig
Udvardy, Miklos
Crawley, Charles
Arcese, William
Mariette, Clara
Hunter, Ann
Leleu, Xavier
Schipperus, Martin
Delforge, Michel
Pioltelli, Pietro
Snowden, John A.
Itälä-Remes, Maija
Musso, Maurizio
van Biezen, Anja
Garderet, Laurent
Kröger, Nicolaus
author_sort Gagelmann, Nico
collection PubMed
description We investigated extramedullary disease in newly diagnosed multiple myeloma patients and its impact on outcome following first-line autologous stem cell transplantation. We identified 3744 adult myeloma patients who received up-front single (n=3391) or tandem transplantation (n=353) between 2005 and 2014 with available data on extramedullary involvement at diagnosis. The overall incidence of extramedullary disease was 18.2% (n=682) and increased per year from 6.5% (2005) to 23.7% (2014). Paraskeletal involvement was found in 543 (14.5%) and extramedullary organ involvement in 139 (3.7%). More patients with extramedullary organ involvement had multiple involved sites (≥2; P<0.001). In a comparison of patients with single sites with patients without the disease, up-front transplantation resulted in at least similar 3-year progression-free survival (paraskeletal: P=0.86, and extramedullary organ: P=0.88). In single paraskeletal involvement, this translated less clearly into worse 3-year overall survival (P=0.07) while single organ involvement was significantly worse (P=0.001). Multiple organ sites were associated with worse outcome (P<0.001 and P=0.01). First-line treatment with tandem compared with single transplantation resulted in similar survival in patients with extramedullary disease at diagnosis (P=0.13 for both).
format Online
Article
Text
id pubmed-5927971
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Ferrata Storti Foundation
record_format MEDLINE/PubMed
spelling pubmed-59279712018-05-15 Impact of extramedullary disease in patients with newly diagnosed multiple myeloma undergoing autologous stem cell transplantation: a study from the Chronic Malignancies Working Party of the EBMT Gagelmann, Nico Eikema, Diderik-Jan Iacobelli, Simona Koster, Linda Nahi, Hareth Stoppa, Anne-Marie Masszi, Tamás Caillot, Denis Lenhoff, Stig Udvardy, Miklos Crawley, Charles Arcese, William Mariette, Clara Hunter, Ann Leleu, Xavier Schipperus, Martin Delforge, Michel Pioltelli, Pietro Snowden, John A. Itälä-Remes, Maija Musso, Maurizio van Biezen, Anja Garderet, Laurent Kröger, Nicolaus Haematologica Article We investigated extramedullary disease in newly diagnosed multiple myeloma patients and its impact on outcome following first-line autologous stem cell transplantation. We identified 3744 adult myeloma patients who received up-front single (n=3391) or tandem transplantation (n=353) between 2005 and 2014 with available data on extramedullary involvement at diagnosis. The overall incidence of extramedullary disease was 18.2% (n=682) and increased per year from 6.5% (2005) to 23.7% (2014). Paraskeletal involvement was found in 543 (14.5%) and extramedullary organ involvement in 139 (3.7%). More patients with extramedullary organ involvement had multiple involved sites (≥2; P<0.001). In a comparison of patients with single sites with patients without the disease, up-front transplantation resulted in at least similar 3-year progression-free survival (paraskeletal: P=0.86, and extramedullary organ: P=0.88). In single paraskeletal involvement, this translated less clearly into worse 3-year overall survival (P=0.07) while single organ involvement was significantly worse (P=0.001). Multiple organ sites were associated with worse outcome (P<0.001 and P=0.01). First-line treatment with tandem compared with single transplantation resulted in similar survival in patients with extramedullary disease at diagnosis (P=0.13 for both). Ferrata Storti Foundation 2018-05 /pmc/articles/PMC5927971/ /pubmed/29419433 http://dx.doi.org/10.3324/haematol.2017.178434 Text en Copyright © 2018 Ferrata Storti Foundation Material published in Haematologica is covered by copyright. All rights are reserved to the Ferrata Storti Foundation. Use of published material is allowed under the following terms and conditions: https://creativecommons.org/licenses/by-nc/4.0/legalcode. Copies of published material are allowed for personal or internal use. Sharing published material for non-commercial purposes is subject to the following conditions: https://creativecommons.org/licenses/by-nc/4.0/legalcode, sect. 3. Reproducing and sharing published material for commercial purposes is not allowed without permission in writing from the publisher.
spellingShingle Article
Gagelmann, Nico
Eikema, Diderik-Jan
Iacobelli, Simona
Koster, Linda
Nahi, Hareth
Stoppa, Anne-Marie
Masszi, Tamás
Caillot, Denis
Lenhoff, Stig
Udvardy, Miklos
Crawley, Charles
Arcese, William
Mariette, Clara
Hunter, Ann
Leleu, Xavier
Schipperus, Martin
Delforge, Michel
Pioltelli, Pietro
Snowden, John A.
Itälä-Remes, Maija
Musso, Maurizio
van Biezen, Anja
Garderet, Laurent
Kröger, Nicolaus
Impact of extramedullary disease in patients with newly diagnosed multiple myeloma undergoing autologous stem cell transplantation: a study from the Chronic Malignancies Working Party of the EBMT
title Impact of extramedullary disease in patients with newly diagnosed multiple myeloma undergoing autologous stem cell transplantation: a study from the Chronic Malignancies Working Party of the EBMT
title_full Impact of extramedullary disease in patients with newly diagnosed multiple myeloma undergoing autologous stem cell transplantation: a study from the Chronic Malignancies Working Party of the EBMT
title_fullStr Impact of extramedullary disease in patients with newly diagnosed multiple myeloma undergoing autologous stem cell transplantation: a study from the Chronic Malignancies Working Party of the EBMT
title_full_unstemmed Impact of extramedullary disease in patients with newly diagnosed multiple myeloma undergoing autologous stem cell transplantation: a study from the Chronic Malignancies Working Party of the EBMT
title_short Impact of extramedullary disease in patients with newly diagnosed multiple myeloma undergoing autologous stem cell transplantation: a study from the Chronic Malignancies Working Party of the EBMT
title_sort impact of extramedullary disease in patients with newly diagnosed multiple myeloma undergoing autologous stem cell transplantation: a study from the chronic malignancies working party of the ebmt
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927971/
https://www.ncbi.nlm.nih.gov/pubmed/29419433
http://dx.doi.org/10.3324/haematol.2017.178434
work_keys_str_mv AT gagelmannnico impactofextramedullarydiseaseinpatientswithnewlydiagnosedmultiplemyelomaundergoingautologousstemcelltransplantationastudyfromthechronicmalignanciesworkingpartyoftheebmt
AT eikemadiderikjan impactofextramedullarydiseaseinpatientswithnewlydiagnosedmultiplemyelomaundergoingautologousstemcelltransplantationastudyfromthechronicmalignanciesworkingpartyoftheebmt
AT iacobellisimona impactofextramedullarydiseaseinpatientswithnewlydiagnosedmultiplemyelomaundergoingautologousstemcelltransplantationastudyfromthechronicmalignanciesworkingpartyoftheebmt
AT kosterlinda impactofextramedullarydiseaseinpatientswithnewlydiagnosedmultiplemyelomaundergoingautologousstemcelltransplantationastudyfromthechronicmalignanciesworkingpartyoftheebmt
AT nahihareth impactofextramedullarydiseaseinpatientswithnewlydiagnosedmultiplemyelomaundergoingautologousstemcelltransplantationastudyfromthechronicmalignanciesworkingpartyoftheebmt
AT stoppaannemarie impactofextramedullarydiseaseinpatientswithnewlydiagnosedmultiplemyelomaundergoingautologousstemcelltransplantationastudyfromthechronicmalignanciesworkingpartyoftheebmt
AT masszitamas impactofextramedullarydiseaseinpatientswithnewlydiagnosedmultiplemyelomaundergoingautologousstemcelltransplantationastudyfromthechronicmalignanciesworkingpartyoftheebmt
AT caillotdenis impactofextramedullarydiseaseinpatientswithnewlydiagnosedmultiplemyelomaundergoingautologousstemcelltransplantationastudyfromthechronicmalignanciesworkingpartyoftheebmt
AT lenhoffstig impactofextramedullarydiseaseinpatientswithnewlydiagnosedmultiplemyelomaundergoingautologousstemcelltransplantationastudyfromthechronicmalignanciesworkingpartyoftheebmt
AT udvardymiklos impactofextramedullarydiseaseinpatientswithnewlydiagnosedmultiplemyelomaundergoingautologousstemcelltransplantationastudyfromthechronicmalignanciesworkingpartyoftheebmt
AT crawleycharles impactofextramedullarydiseaseinpatientswithnewlydiagnosedmultiplemyelomaundergoingautologousstemcelltransplantationastudyfromthechronicmalignanciesworkingpartyoftheebmt
AT arcesewilliam impactofextramedullarydiseaseinpatientswithnewlydiagnosedmultiplemyelomaundergoingautologousstemcelltransplantationastudyfromthechronicmalignanciesworkingpartyoftheebmt
AT marietteclara impactofextramedullarydiseaseinpatientswithnewlydiagnosedmultiplemyelomaundergoingautologousstemcelltransplantationastudyfromthechronicmalignanciesworkingpartyoftheebmt
AT hunterann impactofextramedullarydiseaseinpatientswithnewlydiagnosedmultiplemyelomaundergoingautologousstemcelltransplantationastudyfromthechronicmalignanciesworkingpartyoftheebmt
AT leleuxavier impactofextramedullarydiseaseinpatientswithnewlydiagnosedmultiplemyelomaundergoingautologousstemcelltransplantationastudyfromthechronicmalignanciesworkingpartyoftheebmt
AT schipperusmartin impactofextramedullarydiseaseinpatientswithnewlydiagnosedmultiplemyelomaundergoingautologousstemcelltransplantationastudyfromthechronicmalignanciesworkingpartyoftheebmt
AT delforgemichel impactofextramedullarydiseaseinpatientswithnewlydiagnosedmultiplemyelomaundergoingautologousstemcelltransplantationastudyfromthechronicmalignanciesworkingpartyoftheebmt
AT pioltellipietro impactofextramedullarydiseaseinpatientswithnewlydiagnosedmultiplemyelomaundergoingautologousstemcelltransplantationastudyfromthechronicmalignanciesworkingpartyoftheebmt
AT snowdenjohna impactofextramedullarydiseaseinpatientswithnewlydiagnosedmultiplemyelomaundergoingautologousstemcelltransplantationastudyfromthechronicmalignanciesworkingpartyoftheebmt
AT italaremesmaija impactofextramedullarydiseaseinpatientswithnewlydiagnosedmultiplemyelomaundergoingautologousstemcelltransplantationastudyfromthechronicmalignanciesworkingpartyoftheebmt
AT mussomaurizio impactofextramedullarydiseaseinpatientswithnewlydiagnosedmultiplemyelomaundergoingautologousstemcelltransplantationastudyfromthechronicmalignanciesworkingpartyoftheebmt
AT vanbiezenanja impactofextramedullarydiseaseinpatientswithnewlydiagnosedmultiplemyelomaundergoingautologousstemcelltransplantationastudyfromthechronicmalignanciesworkingpartyoftheebmt
AT garderetlaurent impactofextramedullarydiseaseinpatientswithnewlydiagnosedmultiplemyelomaundergoingautologousstemcelltransplantationastudyfromthechronicmalignanciesworkingpartyoftheebmt
AT krogernicolaus impactofextramedullarydiseaseinpatientswithnewlydiagnosedmultiplemyelomaundergoingautologousstemcelltransplantationastudyfromthechronicmalignanciesworkingpartyoftheebmt