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Appetitive and reactive aggression are differentially associated with the STin2 genetic variant in the serotonin transporter gene

Appetitive aggression is a sub-category of instrumental aggression, characterised by the primary intrinsic enjoyment of aggressive activity. Aggression is heritable, and serotonergic and monoaminergic neurotransmitter systems have been found to contribute to the underlying molecular mechanisms. The...

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Autores principales: Hemmings, Sian Megan Joanna, Xulu, Khethelo, Sommer, Jessica, Hinsberger, Martina, Malan-Muller, Stefanie, Tromp, Gerard, Elbert, Thomas, Weierstall, Roland, Seedat, Soraya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928100/
https://www.ncbi.nlm.nih.gov/pubmed/29712944
http://dx.doi.org/10.1038/s41598-018-25066-8
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author Hemmings, Sian Megan Joanna
Xulu, Khethelo
Sommer, Jessica
Hinsberger, Martina
Malan-Muller, Stefanie
Tromp, Gerard
Elbert, Thomas
Weierstall, Roland
Seedat, Soraya
author_facet Hemmings, Sian Megan Joanna
Xulu, Khethelo
Sommer, Jessica
Hinsberger, Martina
Malan-Muller, Stefanie
Tromp, Gerard
Elbert, Thomas
Weierstall, Roland
Seedat, Soraya
author_sort Hemmings, Sian Megan Joanna
collection PubMed
description Appetitive aggression is a sub-category of instrumental aggression, characterised by the primary intrinsic enjoyment of aggressive activity. Aggression is heritable, and serotonergic and monoaminergic neurotransmitter systems have been found to contribute to the underlying molecular mechanisms. The aim of this study was to investigate the role that genetic variants in the serotonin transporter (SLC6A4) and monoamine oxidase A (MAOA) genes play in the aetiology of appetitive aggression in South African Xhosa males (n = 290). SLC6A4 5-HTTLPR, rs25531, and STin2 variants, as well as MAOA-uVNTR were investigated for their association with levels of appetitive aggression using Poisson regression analysis. The STin2 VNTR12 allele was found to be associated with increased levels of appetitive aggression (p = 0.003), but with decreased levels of reactive aggression (p = 7 × 10(−5)). This study is the first to investigate genetic underpinnings of appetitive aggression in a South African population, with preliminary evidence suggesting that SCL6A4 STin2 variants play a role in its aetiology, and may also be important in differentiating between appetitive and reactive aggression. Although the results require replication, they shed some preliminary light on the molecular dichotomy that may underlie the two forms of aggression.
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spelling pubmed-59281002018-05-07 Appetitive and reactive aggression are differentially associated with the STin2 genetic variant in the serotonin transporter gene Hemmings, Sian Megan Joanna Xulu, Khethelo Sommer, Jessica Hinsberger, Martina Malan-Muller, Stefanie Tromp, Gerard Elbert, Thomas Weierstall, Roland Seedat, Soraya Sci Rep Article Appetitive aggression is a sub-category of instrumental aggression, characterised by the primary intrinsic enjoyment of aggressive activity. Aggression is heritable, and serotonergic and monoaminergic neurotransmitter systems have been found to contribute to the underlying molecular mechanisms. The aim of this study was to investigate the role that genetic variants in the serotonin transporter (SLC6A4) and monoamine oxidase A (MAOA) genes play in the aetiology of appetitive aggression in South African Xhosa males (n = 290). SLC6A4 5-HTTLPR, rs25531, and STin2 variants, as well as MAOA-uVNTR were investigated for their association with levels of appetitive aggression using Poisson regression analysis. The STin2 VNTR12 allele was found to be associated with increased levels of appetitive aggression (p = 0.003), but with decreased levels of reactive aggression (p = 7 × 10(−5)). This study is the first to investigate genetic underpinnings of appetitive aggression in a South African population, with preliminary evidence suggesting that SCL6A4 STin2 variants play a role in its aetiology, and may also be important in differentiating between appetitive and reactive aggression. Although the results require replication, they shed some preliminary light on the molecular dichotomy that may underlie the two forms of aggression. Nature Publishing Group UK 2018-04-30 /pmc/articles/PMC5928100/ /pubmed/29712944 http://dx.doi.org/10.1038/s41598-018-25066-8 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Hemmings, Sian Megan Joanna
Xulu, Khethelo
Sommer, Jessica
Hinsberger, Martina
Malan-Muller, Stefanie
Tromp, Gerard
Elbert, Thomas
Weierstall, Roland
Seedat, Soraya
Appetitive and reactive aggression are differentially associated with the STin2 genetic variant in the serotonin transporter gene
title Appetitive and reactive aggression are differentially associated with the STin2 genetic variant in the serotonin transporter gene
title_full Appetitive and reactive aggression are differentially associated with the STin2 genetic variant in the serotonin transporter gene
title_fullStr Appetitive and reactive aggression are differentially associated with the STin2 genetic variant in the serotonin transporter gene
title_full_unstemmed Appetitive and reactive aggression are differentially associated with the STin2 genetic variant in the serotonin transporter gene
title_short Appetitive and reactive aggression are differentially associated with the STin2 genetic variant in the serotonin transporter gene
title_sort appetitive and reactive aggression are differentially associated with the stin2 genetic variant in the serotonin transporter gene
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928100/
https://www.ncbi.nlm.nih.gov/pubmed/29712944
http://dx.doi.org/10.1038/s41598-018-25066-8
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