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Association between maternal exposure to phthalates and lower language ability in offspring derived from hair metabolome analysis

The fetus undergoes a crucial period of neurodevelopment in utero. The maternal hair metabolome provides an integrated record of the metabolic state of the mother prior to, and during pregnancy. We investigated whether variation in the maternal hair metabolome was associated with neurodevelopmental...

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Autores principales: Jones, Beatrix, Han, Ting-Li, Delplancke, Thibaut, McKenzie, Elizabeth J., de Seymour, Jamie V., Chua, Mei Chien, Tan, Kok Hian, Baker, Philip N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928220/
https://www.ncbi.nlm.nih.gov/pubmed/29712949
http://dx.doi.org/10.1038/s41598-018-24936-5
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author Jones, Beatrix
Han, Ting-Li
Delplancke, Thibaut
McKenzie, Elizabeth J.
de Seymour, Jamie V.
Chua, Mei Chien
Tan, Kok Hian
Baker, Philip N.
author_facet Jones, Beatrix
Han, Ting-Li
Delplancke, Thibaut
McKenzie, Elizabeth J.
de Seymour, Jamie V.
Chua, Mei Chien
Tan, Kok Hian
Baker, Philip N.
author_sort Jones, Beatrix
collection PubMed
description The fetus undergoes a crucial period of neurodevelopment in utero. The maternal hair metabolome provides an integrated record of the metabolic state of the mother prior to, and during pregnancy. We investigated whether variation in the maternal hair metabolome was associated with neurodevelopmental differences across infants. Maternal hair samples and infant neurocognitive assessments (using the Bayley III Scales of Infant Development at 24 months) were obtained for 373 infant-mother dyads between 26–28 weeks’ gestation from the Growing Up in Singapore Towards Healthy Outcomes cohort. The hair metabolome was analysed using gas chromatography-mass spectrometry. Intensity measurements were obtained for 276 compounds. After controlling for maternal education, ethnicity, and infant sex, associations between metabolites and expressive language skills were detected, but not for receptive language, cognitive or motor skills. The results confirm previous research associating higher levels of phthalates with lower language ability. In addition, scores were positively associated with a cluster of compounds, including adipic acid and medium-chain fatty acids. The data support associations between the maternal hair metabolome and neurodevelopmental processes of the fetus. The association between phthalates and lower language ability highlights a modifiable risk factor that warrants further investigation.
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spelling pubmed-59282202018-05-07 Association between maternal exposure to phthalates and lower language ability in offspring derived from hair metabolome analysis Jones, Beatrix Han, Ting-Li Delplancke, Thibaut McKenzie, Elizabeth J. de Seymour, Jamie V. Chua, Mei Chien Tan, Kok Hian Baker, Philip N. Sci Rep Article The fetus undergoes a crucial period of neurodevelopment in utero. The maternal hair metabolome provides an integrated record of the metabolic state of the mother prior to, and during pregnancy. We investigated whether variation in the maternal hair metabolome was associated with neurodevelopmental differences across infants. Maternal hair samples and infant neurocognitive assessments (using the Bayley III Scales of Infant Development at 24 months) were obtained for 373 infant-mother dyads between 26–28 weeks’ gestation from the Growing Up in Singapore Towards Healthy Outcomes cohort. The hair metabolome was analysed using gas chromatography-mass spectrometry. Intensity measurements were obtained for 276 compounds. After controlling for maternal education, ethnicity, and infant sex, associations between metabolites and expressive language skills were detected, but not for receptive language, cognitive or motor skills. The results confirm previous research associating higher levels of phthalates with lower language ability. In addition, scores were positively associated with a cluster of compounds, including adipic acid and medium-chain fatty acids. The data support associations between the maternal hair metabolome and neurodevelopmental processes of the fetus. The association between phthalates and lower language ability highlights a modifiable risk factor that warrants further investigation. Nature Publishing Group UK 2018-04-30 /pmc/articles/PMC5928220/ /pubmed/29712949 http://dx.doi.org/10.1038/s41598-018-24936-5 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Jones, Beatrix
Han, Ting-Li
Delplancke, Thibaut
McKenzie, Elizabeth J.
de Seymour, Jamie V.
Chua, Mei Chien
Tan, Kok Hian
Baker, Philip N.
Association between maternal exposure to phthalates and lower language ability in offspring derived from hair metabolome analysis
title Association between maternal exposure to phthalates and lower language ability in offspring derived from hair metabolome analysis
title_full Association between maternal exposure to phthalates and lower language ability in offspring derived from hair metabolome analysis
title_fullStr Association between maternal exposure to phthalates and lower language ability in offspring derived from hair metabolome analysis
title_full_unstemmed Association between maternal exposure to phthalates and lower language ability in offspring derived from hair metabolome analysis
title_short Association between maternal exposure to phthalates and lower language ability in offspring derived from hair metabolome analysis
title_sort association between maternal exposure to phthalates and lower language ability in offspring derived from hair metabolome analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928220/
https://www.ncbi.nlm.nih.gov/pubmed/29712949
http://dx.doi.org/10.1038/s41598-018-24936-5
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