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Mechanisms involved in adenosine pharmacological preconditioning-induced cardioprotection

Adenosine is a naturally occurring breakdown product of adenosine triphosphate and plays an important role in different physiological and pathological conditions. Adenosine also serves as an important trigger in ischemic and remote preconditioning and its release may impart cardioprotection. Exogeno...

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Autores principales: Singh, Lovedeep, Kulshrestha, Ritu, Singh, Nirmal, Jaggi, Amteshwar Singh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Physiological Society and The Korean Society of Pharmacology 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928336/
https://www.ncbi.nlm.nih.gov/pubmed/29719445
http://dx.doi.org/10.4196/kjpp.2018.22.3.225
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author Singh, Lovedeep
Kulshrestha, Ritu
Singh, Nirmal
Jaggi, Amteshwar Singh
author_facet Singh, Lovedeep
Kulshrestha, Ritu
Singh, Nirmal
Jaggi, Amteshwar Singh
author_sort Singh, Lovedeep
collection PubMed
description Adenosine is a naturally occurring breakdown product of adenosine triphosphate and plays an important role in different physiological and pathological conditions. Adenosine also serves as an important trigger in ischemic and remote preconditioning and its release may impart cardioprotection. Exogenous administration of adenosine in the form of adenosine preconditioning may also protect heart from ischemia-reperfusion injury. Endogenous release of adenosine during ischemic/remote preconditioning or exogenous adenosine during pharmacological preconditioning activates adenosine receptors to activate plethora of mechanisms, which either independently or in association with one another may confer cardioprotection during ischemia-reperfusion injury. These mechanisms include activation of K(ATP) channels, an increase in the levels of antioxidant enzymes, functional interaction with opioid receptors; increase in nitric oxide production; decrease in inflammation; activation of transient receptor potential vanilloid (TRPV) channels; activation of kinases such as protein kinase B (Akt), protein kinase C, tyrosine kinase, mitogen activated protein (MAP) kinases such as ERK 1/2, p38 MAP kinases and MAP kinase kinase (MEK 1) MMP. The present review discusses the role and mechanisms involved in adenosine preconditioning-induced cardioprotection.
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spelling pubmed-59283362018-05-01 Mechanisms involved in adenosine pharmacological preconditioning-induced cardioprotection Singh, Lovedeep Kulshrestha, Ritu Singh, Nirmal Jaggi, Amteshwar Singh Korean J Physiol Pharmacol Review Article Adenosine is a naturally occurring breakdown product of adenosine triphosphate and plays an important role in different physiological and pathological conditions. Adenosine also serves as an important trigger in ischemic and remote preconditioning and its release may impart cardioprotection. Exogenous administration of adenosine in the form of adenosine preconditioning may also protect heart from ischemia-reperfusion injury. Endogenous release of adenosine during ischemic/remote preconditioning or exogenous adenosine during pharmacological preconditioning activates adenosine receptors to activate plethora of mechanisms, which either independently or in association with one another may confer cardioprotection during ischemia-reperfusion injury. These mechanisms include activation of K(ATP) channels, an increase in the levels of antioxidant enzymes, functional interaction with opioid receptors; increase in nitric oxide production; decrease in inflammation; activation of transient receptor potential vanilloid (TRPV) channels; activation of kinases such as protein kinase B (Akt), protein kinase C, tyrosine kinase, mitogen activated protein (MAP) kinases such as ERK 1/2, p38 MAP kinases and MAP kinase kinase (MEK 1) MMP. The present review discusses the role and mechanisms involved in adenosine preconditioning-induced cardioprotection. The Korean Physiological Society and The Korean Society of Pharmacology 2018-05 2018-04-25 /pmc/articles/PMC5928336/ /pubmed/29719445 http://dx.doi.org/10.4196/kjpp.2018.22.3.225 Text en Copyright © Korean J Physiol Pharmacol http://creativecommons.org/licenses/by-nc/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Singh, Lovedeep
Kulshrestha, Ritu
Singh, Nirmal
Jaggi, Amteshwar Singh
Mechanisms involved in adenosine pharmacological preconditioning-induced cardioprotection
title Mechanisms involved in adenosine pharmacological preconditioning-induced cardioprotection
title_full Mechanisms involved in adenosine pharmacological preconditioning-induced cardioprotection
title_fullStr Mechanisms involved in adenosine pharmacological preconditioning-induced cardioprotection
title_full_unstemmed Mechanisms involved in adenosine pharmacological preconditioning-induced cardioprotection
title_short Mechanisms involved in adenosine pharmacological preconditioning-induced cardioprotection
title_sort mechanisms involved in adenosine pharmacological preconditioning-induced cardioprotection
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928336/
https://www.ncbi.nlm.nih.gov/pubmed/29719445
http://dx.doi.org/10.4196/kjpp.2018.22.3.225
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