Overexpression of Tpl2 is linked to imatinib resistance and activation of MEK‐ERK and NF‐κB pathways in a model of chronic myeloid leukemia

The introduction of tyrosine kinase inhibitors (TKI) has transformed chronic myeloid leukemia (CML) into a chronic disease with long‐term survival exceeding 85%. However, resistance of CML stem cells to TKI may contribute to the 50% relapse rate observed after TKI discontinuation in molecular remiss...

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Detalles Bibliográficos
Autores principales: Chorzalska, Anna, Ahsan, Nagib, Rao, R. Shyama Prasad, Roder, Karim, Yu, Xiaoqing, Morgan, John, Tepper, Alexander, Hines, Steven, Zhang, Peng, Treaba, Diana O., Zhao, Ting C., Olszewski, Adam J., Reagan, John L., Liang, Olin, Gruppuso, Philip A., Dubielecka, Patrycja M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928369/
https://www.ncbi.nlm.nih.gov/pubmed/29485707
http://dx.doi.org/10.1002/1878-0261.12186

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