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High Complement Factor H-Related (FHR)-3 Levels Are Associated With the Atypical Hemolytic-Uremic Syndrome-Risk Allele CFHR3*B
Dysregulation of the complement alternative pathway (AP) is a major pathogenic mechanism in atypical hemolytic-uremic syndrome (aHUS). Genetic or acquired defects in factor H (FH), the main AP regulator, are major aHUS drivers that associate with a poor prognosis. FH activity has been suggested to b...
Autores principales: | Pouw, Richard B., Gómez Delgado, Irene, López Lera, Alberto, Rodríguez de Córdoba, Santiago, Wouters, Diana, Kuijpers, Taco W., Sánchez-Corral, Pilar |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928496/ https://www.ncbi.nlm.nih.gov/pubmed/29740447 http://dx.doi.org/10.3389/fimmu.2018.00848 |
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