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Placental expression of PAPPA, PAPPA-2 and PLAC-1 in pregnacies is associated with FGR

Fetal growth restriction (FGR) is a gynecological disorder of varying etiology. In the present study, an expression analysis of pregnancy-associated plasma protein A (PAPPA), pregnancy-associated plasma protein A2 (PAPPA2) and placenta-specific-1 (PLAC-1) was conducted in pregnancies with FGR and co...

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Autores principales: Sifakis, Stavros, Androutsopoulos, Vasilis P., Pontikaki, Artemis, Velegrakis, Alexis, Papaioannou, George I., Koukoura, Ourania, Spandidos, Demetrios A., Papantoniou, Nikos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928614/
https://www.ncbi.nlm.nih.gov/pubmed/29532882
http://dx.doi.org/10.3892/mmr.2018.8721
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author Sifakis, Stavros
Androutsopoulos, Vasilis P.
Pontikaki, Artemis
Velegrakis, Alexis
Papaioannou, George I.
Koukoura, Ourania
Spandidos, Demetrios A.
Papantoniou, Nikos
author_facet Sifakis, Stavros
Androutsopoulos, Vasilis P.
Pontikaki, Artemis
Velegrakis, Alexis
Papaioannou, George I.
Koukoura, Ourania
Spandidos, Demetrios A.
Papantoniou, Nikos
author_sort Sifakis, Stavros
collection PubMed
description Fetal growth restriction (FGR) is a gynecological disorder of varying etiology. In the present study, an expression analysis of pregnancy-associated plasma protein A (PAPPA), pregnancy-associated plasma protein A2 (PAPPA2) and placenta-specific-1 (PLAC-1) was conducted in pregnancies with FGR and control pregnancies. Placental tissues were collected from pregnancies with FGR (n=16) and control pregnancies (n=16) and the expression of the genes of interest was examined by qPCR. The mean expression levels of PAPPA and PAPPA2 were significantly lower (P<0.001) in placental tissues from FGR pregnancies compared with tissues from healthy subjects, whereas the opposite pattern was observed for PLAC-1 (P<0.001). PAPPA and PLAC-1 expression in FGR and control subjects correlated with birth weight (P<0.001). The findings suggest a possible pathophysiological link between the development of FGR and the expression of PAPPA, PAPPA2 and PLAC-1.
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spelling pubmed-59286142018-05-07 Placental expression of PAPPA, PAPPA-2 and PLAC-1 in pregnacies is associated with FGR Sifakis, Stavros Androutsopoulos, Vasilis P. Pontikaki, Artemis Velegrakis, Alexis Papaioannou, George I. Koukoura, Ourania Spandidos, Demetrios A. Papantoniou, Nikos Mol Med Rep Articles Fetal growth restriction (FGR) is a gynecological disorder of varying etiology. In the present study, an expression analysis of pregnancy-associated plasma protein A (PAPPA), pregnancy-associated plasma protein A2 (PAPPA2) and placenta-specific-1 (PLAC-1) was conducted in pregnancies with FGR and control pregnancies. Placental tissues were collected from pregnancies with FGR (n=16) and control pregnancies (n=16) and the expression of the genes of interest was examined by qPCR. The mean expression levels of PAPPA and PAPPA2 were significantly lower (P<0.001) in placental tissues from FGR pregnancies compared with tissues from healthy subjects, whereas the opposite pattern was observed for PLAC-1 (P<0.001). PAPPA and PLAC-1 expression in FGR and control subjects correlated with birth weight (P<0.001). The findings suggest a possible pathophysiological link between the development of FGR and the expression of PAPPA, PAPPA2 and PLAC-1. D.A. Spandidos 2018-05 2018-03-09 /pmc/articles/PMC5928614/ /pubmed/29532882 http://dx.doi.org/10.3892/mmr.2018.8721 Text en Copyright: © Sifakis et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Sifakis, Stavros
Androutsopoulos, Vasilis P.
Pontikaki, Artemis
Velegrakis, Alexis
Papaioannou, George I.
Koukoura, Ourania
Spandidos, Demetrios A.
Papantoniou, Nikos
Placental expression of PAPPA, PAPPA-2 and PLAC-1 in pregnacies is associated with FGR
title Placental expression of PAPPA, PAPPA-2 and PLAC-1 in pregnacies is associated with FGR
title_full Placental expression of PAPPA, PAPPA-2 and PLAC-1 in pregnacies is associated with FGR
title_fullStr Placental expression of PAPPA, PAPPA-2 and PLAC-1 in pregnacies is associated with FGR
title_full_unstemmed Placental expression of PAPPA, PAPPA-2 and PLAC-1 in pregnacies is associated with FGR
title_short Placental expression of PAPPA, PAPPA-2 and PLAC-1 in pregnacies is associated with FGR
title_sort placental expression of pappa, pappa-2 and plac-1 in pregnacies is associated with fgr
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928614/
https://www.ncbi.nlm.nih.gov/pubmed/29532882
http://dx.doi.org/10.3892/mmr.2018.8721
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